Low-level chromosome 12 amplification in a primary lipoma of the lung: Evidence for a pathogenetic relationship with common adipose tissue tumors

Julia A. Bridge, Cory A. Roberts, Joanne Degenhardt, Craig Walker, Rudy P Lackner, James Linder

Research output: Contribution to journalArticle

6 Scopus citations


Cytogenetic analysis of a primary lipoma of the lung removed from a 56- year-old woman revealed the presence of a supernumerary marker chromosome in all metaphase cells analyzed; namely, 47,XX,+mar. To the best of our knowledge, this is the first cytogenetic description of a primary lipoma of lung. Genetic analysis of intramuscular lipoma, atypical lipoma, and well- differentiated liposarcoma have revealed the presence of one to three supernumerary ring or giant marker chromosomes composed of chromosome 12 segments as the characteristic anomaly. The marker chromosome in the present case was shown to be composed entirely of chromosome 12 material by subsequent analysis with a chromosome 12-specific paint probe and fluorescence in situ hybridization. Thus, analogous to intramuscular lipoma, atypical lipoma, and well-differentiated liposarcoma, extra chromosome 12 material is present. These findings support a pathogenetic relationship between this lipoma of unusual anatomic location and common adipose tissue tumors.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number2
Publication statusPublished - Feb 1 1998


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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