Low-Dose Dopamine

A Physiologically Based Review

Paul J Schenarts, Scott G. Sagraves, Michael R. Bard, Eric A. Toschlog, Claudia E. Goettler, Mark A. Newell, Michael F. Rotondo

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Background: In an attempt to prevent or alter the course of acute renal failure, many surgeons continue to use low-dose dopamine. This article critically reviews the physiologic reasons why low-dose dopamine is not clinically efficacious. Methods: A critical review of English language literature. Results: The effect of dopamine on renal blood flow remains controversial. If dopamine does increase renal blood flow, the vascular anatomy of the kidney would limit its effectiveness. Rather than improving renal function, dopamine has been shown to impair renal oxygen kinetics, inhibit feedback systems that protect the kidney from ischemia, and may worsen tubular injury. Dopamine has not been proven useful in the prevention or alteration of the course of acute renal failure as a result of heart failure, cardiac surgery, abdominal aortic surgery, sepsis, and transplantation. Dopamine has been associated with multiple complications involving the cardiovascular, pulmonary, gastrointestinal, endocrine, and immune systems. Conclusions: Based on the anatomy and physiology of the kidney, low-dose dopamine would not be expected to improve renal failure and this has been demonstrated by the lack of efficacy in clinical trials.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalCurrent surgery
Volume63
Issue number3
DOIs
StatePublished - May 1 2006

Fingerprint

Dopamine
surgery
Kidney
Renal Circulation
physiology
Acute Kidney Injury
English language
Anatomy
Endocrine System
lack
Thoracic Surgery
Renal Insufficiency
Blood Vessels
Immune System
Sepsis
Language
Ischemia
Heart Failure
Transplantation
Clinical Trials

Keywords

  • Dopamine
  • critical care
  • renal blood flow
  • renal failure

ASJC Scopus subject areas

  • Surgery

Cite this

Schenarts, P. J., Sagraves, S. G., Bard, M. R., Toschlog, E. A., Goettler, C. E., Newell, M. A., & Rotondo, M. F. (2006). Low-Dose Dopamine: A Physiologically Based Review. Current surgery, 63(3), 219-225. https://doi.org/10.1016/j.cursur.2005.08.008

Low-Dose Dopamine : A Physiologically Based Review. / Schenarts, Paul J; Sagraves, Scott G.; Bard, Michael R.; Toschlog, Eric A.; Goettler, Claudia E.; Newell, Mark A.; Rotondo, Michael F.

In: Current surgery, Vol. 63, No. 3, 01.05.2006, p. 219-225.

Research output: Contribution to journalReview article

Schenarts, PJ, Sagraves, SG, Bard, MR, Toschlog, EA, Goettler, CE, Newell, MA & Rotondo, MF 2006, 'Low-Dose Dopamine: A Physiologically Based Review', Current surgery, vol. 63, no. 3, pp. 219-225. https://doi.org/10.1016/j.cursur.2005.08.008
Schenarts PJ, Sagraves SG, Bard MR, Toschlog EA, Goettler CE, Newell MA et al. Low-Dose Dopamine: A Physiologically Based Review. Current surgery. 2006 May 1;63(3):219-225. https://doi.org/10.1016/j.cursur.2005.08.008
Schenarts, Paul J ; Sagraves, Scott G. ; Bard, Michael R. ; Toschlog, Eric A. ; Goettler, Claudia E. ; Newell, Mark A. ; Rotondo, Michael F. / Low-Dose Dopamine : A Physiologically Based Review. In: Current surgery. 2006 ; Vol. 63, No. 3. pp. 219-225.
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