Low-dose aspirin does not attenuate platelet aggregation or atherosclerosis in miniature swine but decreases production of aortic wall prostacyclin

M. J. Smith, K. G.D. Allen, J. F. Norman, M. A. Harris, C. W. Miller

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The objectives of this study were to determine if, and at what dose, aspirin could attenuate atherosclerosis in hypercholesterolemic Yucatan miniature swine, and to determine the influence of aspirin on aortic wall prostacyclin production and platelet aggregation. 30 Yucatan miniature swine (age 3 months) were fed either regular diet (RD), atherogenic diet (AD), or AD plus one of four aspirin dosages (2,4,8, or 16 mg/kg/d) for 6 months. The extent of atherosclerotic lesions in the abdominal aorta and coronary arteries was evaluated by sudanophilic staining and histological grading using Stary's classification, respectively. Aortic wall production of prostacyclin (PGI2) and platelet aggregation were assessed. Lesions were similar among the AD groups (45.3 ± 4.3%) and significantly higher than RD (1.4 ± 0.4%). PGI2 production was significantly lower (p < 0.05) in all aspirin-treated groups. Platelet aggregation was not affected by treatment. It is concluded that the range of aspirin dosages (2-16 mg/kg/d) does not attenuate the development of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)331-340
Number of pages10
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume53
Issue number5
DOIs
StatePublished - Nov 1995

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Miniature Swine
Epoprostenol
Nutrition
Platelets
Platelet Aggregation
Aspirin
Atherosclerosis
Atherogenic Diet
Agglomeration
Diet
Abdominal Aorta
Coronary Vessels
Staining and Labeling

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

Low-dose aspirin does not attenuate platelet aggregation or atherosclerosis in miniature swine but decreases production of aortic wall prostacyclin. / Smith, M. J.; Allen, K. G.D.; Norman, J. F.; Harris, M. A.; Miller, C. W.

In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 53, No. 5, 11.1995, p. 331-340.

Research output: Contribution to journalArticle

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