Loss of fibulin-2 expression is associated with breast cancer progression

Chun Hui Yi, David J. Smith, William W. West, Michael A Hollingsworth

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.

Original languageEnglish (US)
Pages (from-to)1535-1545
Number of pages11
JournalAmerican Journal of Pathology
Volume170
Issue number5
DOIs
StatePublished - Jan 1 2007

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Breast Neoplasms
Cell Movement
Cell Line
Extracellular Matrix Proteins
Cell Adhesion
Wound Healing
Smooth Muscle Myocytes
fibulin 2
Epithelium
Immunohistochemistry
Growth
Neoplasms
Proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Loss of fibulin-2 expression is associated with breast cancer progression. / Yi, Chun Hui; Smith, David J.; West, William W.; Hollingsworth, Michael A.

In: American Journal of Pathology, Vol. 170, No. 5, 01.01.2007, p. 1535-1545.

Research output: Contribution to journalArticle

Yi, Chun Hui ; Smith, David J. ; West, William W. ; Hollingsworth, Michael A. / Loss of fibulin-2 expression is associated with breast cancer progression. In: American Journal of Pathology. 2007 ; Vol. 170, No. 5. pp. 1535-1545.
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