Loss of fibulin-2 expression is associated with breast cancer progression

Chun Hui Yi, David J. Smith, William W. West, Michael A. Hollingsworth

Research output: Contribution to journalArticle

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Abstract

Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.

Original languageEnglish (US)
Pages (from-to)1535-1545
Number of pages11
JournalAmerican Journal of Pathology
Volume170
Issue number5
DOIs
StatePublished - May 2007

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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