Loss of an X chromosome in aggressive angiomyxoma of female soft parts: A case report

Mary B. Kenny-Moynihan, Jedd Hagen, Brett Richman, David G. McIntosh, Julia A. Bridge

Research output: Contribution to journalArticle

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Abstract

Cytogenetic analysis of an aggressive angiomyxoma of the vulvar region of a 16-year-old female revealed loss of one X chromosome (45,X,-X) in eight of 20 metaphase cells analyzed. Fluorescence in situ hybridization (FISH) performed on disaggregated cells from paraffin embedded lesional tissue confirmed loss of an X chromosome in 31% of cells. Cytogenetic analysis performed on peripheral blood showed a normal chromosomal complement (46,XX). Thus, loss of one X chromosome appears to be confined to the neoplasm. This anomaly has not been previously described in aggressive angiomyxoma.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalCancer genetics and cytogenetics
Volume89
Issue number1
DOIs
Publication statusPublished - Jul 1 1996

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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