Longitudinal development of distortion product otoacoustic emissions in infants with normal hearing

Lisa L. Hunter, Chelsea M. Blankenship, Douglas H. Keefe, M. Patrick Feeney, David K. Brown, Annie McCune, Denis F. Fitzpatrick, Li Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to describe normal characteristics of distortion product otoacoustic emission (DPOAE) signal and noise level in a group of newborns and infants with normal hearing followed longitudinally from birth to 15 months of age. Design: This is a prospective, longitudinal study of 231 infants who passed newborn hearing screening and were verified to have normal hearing. Infants were enrolled from a well-baby nursery and two neonatal intensive care units (NICUs) in Cincinnati, OH. Normal hearing was confirmed with threshold auditory brainstem response and visual reinforcement audiometry. DPOAEs were measured in up to four study visits over the first year after birth. Stimulus frequencies f 1 and f 2 were used with f 2 /f 1 = 1.22, and the DPOAE was recorded at frequency 2f 1 -f 2 . A longitudinal repeated-measure linear mixed model design was used to study changes in DPOAE level and noise level as related to age, middle ear transfer, race, and NICU history. Results: Significant changes in the DPOAE and noise levels occurred from birth to 12 months of age. DPOAE levels were the highest at 1 month of age. The largest decrease in DPOAE level occurred between 1 and 5 months of age in the mid to high frequencies (2 to 8kHz) with minimal changes occurring between 6, 9, and 12 months of age. The decrease in DPOAE level was significantly related to a decrease in wideband absorbance at the same f 2 frequencies. DPOAE noise level increased only slightly with age over the first year with the highest noise levels in the 12-month-old age range. Minor, nonsystematic effects for NICU history, race, and gestational age at birth were found, thus these results were generalizable to commonly seen clinical populations. Conclusions: DPOAE levels were related to wideband middle ear absorbance changes in this large sample of infants confirmed to have normal hearing at auditory brainstem response and visual reinforcement audiometry testing. This normative database can be used to evaluate clinical results from birth to 1 year of age. The distributions of DPOAE level and signal to noise ratio data reported herein across frequency and age in normal-hearing infants who were healthy or had NICU histories may be helpful to detect the presence of hearing loss in infants.

Original languageEnglish (US)
Pages (from-to)863-873
Number of pages11
JournalEar and hearing
Volume39
Issue number5
DOIs
StatePublished - Jan 1 2018

Fingerprint

Hearing
Neonatal Intensive Care Units
Parturition
Noise
Audiometry
Brain Stem Auditory Evoked Potentials
Middle Ear
History
Newborn Infant
Nurseries
Signal-To-Noise Ratio
Hearing Loss
Gestational Age
Longitudinal Studies
Linear Models
Databases
Prospective Studies
Population
Reinforcement (Psychology)

Keywords

  • Distortion product otoacoustic emissions
  • Infants
  • Normal hearing

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing

Cite this

Hunter, L. L., Blankenship, C. M., Keefe, D. H., Patrick Feeney, M., Brown, D. K., McCune, A., ... Lin, L. (2018). Longitudinal development of distortion product otoacoustic emissions in infants with normal hearing. Ear and hearing, 39(5), 863-873. https://doi.org/10.1097/AUD.0000000000000542

Longitudinal development of distortion product otoacoustic emissions in infants with normal hearing. / Hunter, Lisa L.; Blankenship, Chelsea M.; Keefe, Douglas H.; Patrick Feeney, M.; Brown, David K.; McCune, Annie; Fitzpatrick, Denis F.; Lin, Li.

In: Ear and hearing, Vol. 39, No. 5, 01.01.2018, p. 863-873.

Research output: Contribution to journalArticle

Hunter, LL, Blankenship, CM, Keefe, DH, Patrick Feeney, M, Brown, DK, McCune, A, Fitzpatrick, DF & Lin, L 2018, 'Longitudinal development of distortion product otoacoustic emissions in infants with normal hearing', Ear and hearing, vol. 39, no. 5, pp. 863-873. https://doi.org/10.1097/AUD.0000000000000542
Hunter, Lisa L. ; Blankenship, Chelsea M. ; Keefe, Douglas H. ; Patrick Feeney, M. ; Brown, David K. ; McCune, Annie ; Fitzpatrick, Denis F. ; Lin, Li. / Longitudinal development of distortion product otoacoustic emissions in infants with normal hearing. In: Ear and hearing. 2018 ; Vol. 39, No. 5. pp. 863-873.
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