Long-term use of cyclosporine in liver recipients

Reduction of dosages in the first year to avoid nephrotoxicity

Shunzaburo Iwatsuki, Thomas E. Starzl, Byers Wendell Shaw Jr, Shuin L. Yang, Basil J. Zitelli, J. Carlton Gartner, J. Jeffrey Malatack

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Cyclosporine is a potent immunosuppressive drug, which has dose-related nephrotoxicity. In renal transplantation, the differentiation between rejection and toxicity is difficult and even with the aid of blood levels of the drug, it may be difficult to establish a chronic maintenance dose. Long-term survivors after liver transplantation can provide modes with which to establish maintenance doses, as these are dictated by nephrotoxicity in these patients. Twenty-nine liver transplant patients who survived one year or more were followed for changes in their cyclosporine doses. Daily oral cyclosporine dose, BUN, serum creatinine and bilirubin were monitored. The reductions in cyclosporine were dictated almost entirely by the findings of nephrotoxicity.

Original languageEnglish (US)
Pages (from-to)641-643
Number of pages3
JournalTransplantation
Volume36
Issue number6
DOIs
StatePublished - Jan 1 1983

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Cyclosporine
Liver
Blood Urea Nitrogen
Immunosuppressive Agents
Bilirubin
Pharmaceutical Preparations
Liver Transplantation
Kidney Transplantation
Survivors
Creatinine
Transplants
Serum

ASJC Scopus subject areas

  • Transplantation

Cite this

Iwatsuki, S., Starzl, T. E., Shaw Jr, B. W., Yang, S. L., Zitelli, B. J., Gartner, J. C., & Malatack, J. J. (1983). Long-term use of cyclosporine in liver recipients: Reduction of dosages in the first year to avoid nephrotoxicity. Transplantation, 36(6), 641-643. https://doi.org/10.1097/00007890-198336060-00010

Long-term use of cyclosporine in liver recipients : Reduction of dosages in the first year to avoid nephrotoxicity. / Iwatsuki, Shunzaburo; Starzl, Thomas E.; Shaw Jr, Byers Wendell; Yang, Shuin L.; Zitelli, Basil J.; Gartner, J. Carlton; Malatack, J. Jeffrey.

In: Transplantation, Vol. 36, No. 6, 01.01.1983, p. 641-643.

Research output: Contribution to journalArticle

Iwatsuki, S, Starzl, TE, Shaw Jr, BW, Yang, SL, Zitelli, BJ, Gartner, JC & Malatack, JJ 1983, 'Long-term use of cyclosporine in liver recipients: Reduction of dosages in the first year to avoid nephrotoxicity', Transplantation, vol. 36, no. 6, pp. 641-643. https://doi.org/10.1097/00007890-198336060-00010
Iwatsuki, Shunzaburo ; Starzl, Thomas E. ; Shaw Jr, Byers Wendell ; Yang, Shuin L. ; Zitelli, Basil J. ; Gartner, J. Carlton ; Malatack, J. Jeffrey. / Long-term use of cyclosporine in liver recipients : Reduction of dosages in the first year to avoid nephrotoxicity. In: Transplantation. 1983 ; Vol. 36, No. 6. pp. 641-643.
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