Long-term results of intestinal transplantation for pseudo-obstruction in children

K. Iyer, S. Kaufman, D. Sudan, S. Horslen, B. Shaw, I. Fox, Alan Norman Langnas, J. Reyes

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine long-term results of intestinal transplantation in children with pseudo-obstruction, particularly when stomach and colon are not part of the allograft. Methods: The authors conducted a case-record review of all children who underwent transplantation at our center for a primary diagnosis of pseudo-obstruction. Supplementary information was obtained from outpatient charts, computerized database, and telephone survey of parents. Results: Six small bowel and 3 liver-small bowel tranplants were carried out in 8 patients between 1993 and 1999. Median follow-up is 40 months (range, 13 to 73 months). Median age at transplantation was 2.7 years (range, 0.7 to 12.8 years). Median graft survival in this series is 15 months (range, 1 day to 71 months). Stomach and colon were excluded from all allografts. Two children died 5 and 368 days after transplant and 2 graft losses occurred in 1 patient. Two children had lymphoproliferative disease; both are alive with functioning grafts. Five survivors with functioning grafts recieve full enteral feedings at home. Four of the 5 have had ileostomies closed, and 3 have normal bowel movements. Conclusions: Intestinal transplantation without stomach or colon provides children with cronic intestinal pseudo-obstruction with a good quality of life. The underlying disease poses special challenges in management.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalJournal of pediatric surgery
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2001

Fingerprint

Intestinal Pseudo-Obstruction
Transplantation
Transplants
Stomach
Colon
Allografts
Ileostomy
Enteral Nutrition
Graft Survival
Telephone
Survivors
Outpatients
Parents
Quality of Life
Databases
Liver

Keywords

  • Intestinal failure
  • Intestinal transplantation
  • Pseudo-obstruction

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Iyer, K., Kaufman, S., Sudan, D., Horslen, S., Shaw, B., Fox, I., ... Reyes, J. (2001). Long-term results of intestinal transplantation for pseudo-obstruction in children. Journal of pediatric surgery, 36(1), 174-177. https://doi.org/10.1053/jpsu.2001.20046

Long-term results of intestinal transplantation for pseudo-obstruction in children. / Iyer, K.; Kaufman, S.; Sudan, D.; Horslen, S.; Shaw, B.; Fox, I.; Langnas, Alan Norman; Reyes, J.

In: Journal of pediatric surgery, Vol. 36, No. 1, 01.01.2001, p. 174-177.

Research output: Contribution to journalArticle

Iyer, K, Kaufman, S, Sudan, D, Horslen, S, Shaw, B, Fox, I, Langnas, AN & Reyes, J 2001, 'Long-term results of intestinal transplantation for pseudo-obstruction in children', Journal of pediatric surgery, vol. 36, no. 1, pp. 174-177. https://doi.org/10.1053/jpsu.2001.20046
Iyer, K. ; Kaufman, S. ; Sudan, D. ; Horslen, S. ; Shaw, B. ; Fox, I. ; Langnas, Alan Norman ; Reyes, J. / Long-term results of intestinal transplantation for pseudo-obstruction in children. In: Journal of pediatric surgery. 2001 ; Vol. 36, No. 1. pp. 174-177.
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