Long-term follow-up of auxiliary orthotopic liver transplantation for the treatment of fulminant hepatic failure

Debra L. Sudan, Byers W. Shaw, Ira J. Fox, Alan Norman Langnas

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background. Auxiliary orthotopic liver transplantation (AOLT) was investigated as a bridge to native liver recovery in patients with fulminant hepatic failure (FHF). Methods. In the last 5 years seven patients with FHF were treated with AOLT at our institution. Five patients underwent resection of the native left lobe and orthotopic replacement with a donor left lobe (n = 3) or left lateral segment (n = 2). Two patients underwent left trisegmentectomy and whole liver auxiliary grafting. Conventional immunosuppression was used in all patients. Results. One patient had poor initial graft function and required retransplantation. Native liver function returned to normal in the six other patients. Immunosuppression was gradually tapered and completely discontinued in three patients, allowing for atrophy of the allograft. The allograft was removed in the other four patients. Despite evidence of native liver regeneration, two patients with aplastic anemia died after allograft removal. Four patients are alive at a mean follow-up of 3.5 years. Conclusions. AOLT is technically feasible, rapidly restores liver function, and should be considered an important alternative to standard orthotopic liver transplantation (OLT) in the treatment of FHF. AOLT has the advantage that patients transplanted for FHF are not committed to lifelong immunosuppression with its attendant risks.

Original languageEnglish (US)
Pages (from-to)771-778
Number of pages8
JournalSurgery
Volume122
Issue number4
DOIs
StatePublished - Jan 1 1997

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Acute Liver Failure
Liver Transplantation
Therapeutics
Immunosuppression
Allografts
Liver
Liver Regeneration
Aplastic Anemia
Atrophy
Tissue Donors

ASJC Scopus subject areas

  • Surgery

Cite this

Long-term follow-up of auxiliary orthotopic liver transplantation for the treatment of fulminant hepatic failure. / Sudan, Debra L.; Shaw, Byers W.; Fox, Ira J.; Langnas, Alan Norman.

In: Surgery, Vol. 122, No. 4, 01.01.1997, p. 771-778.

Research output: Contribution to journalArticle

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