Long-term effects of Helicobacter pylori infection on acid and pepsin secretion

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Abstract

Chronic Helicobacter pylori infection causes a slight postprandial hypergastrinemia, generally referred to as exaggerated or inappropriate gastrin release. This can be ablated by eradication of this infective agent. The expectations that this would further unravel the mysteries of the pathogenesis of peptic ulcer disease have not been fulfilled. It is now well established that of conventional acid secretory patterns such as basal acid secretion, maximum gastrin-stimulated acid secretion, and of sensitivity of the parietal cell to gastrin, only basal acid is modified by chronic H. pylori colonization. This particularly relates to basal secretion in duodenal ulcer patients, as basal secretion of otherwise healthy, chronically H. pylori-infected subjects appears to be affected in only a small proportion of subjects. It is of particular interest, however, that chronic H. pylori infection supplies a solid explanation why acid inhibitory pathways are deficient in duodenal ulcer disease, since this is reversible following H. pylori eradication as demonstrated by elegant studies with gastrin-releasing, peptide-stimulated acid secretion. Furthermore, it has gradually become apparent that exaggerated gastrin response is probably no more than an innocent bystander of chronic H. pylori infection. Paradoxically, in a small subset of patients, hypo-or anacidity accompanying chrone H. pylori infection can be reverted by H. pylori eradication, for currently unknown reasons. The question remains open whether enhanced pepsin release from the chief cell, which characterizes duodenal ulcer disease and is also reversible following H. pylori eradication, has any direct implication in ulcer expression in duodenal ulcer patients.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalYale Journal of Biology and Medicine
Volume69
Issue number1
StatePublished - Jan 1 1996

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Pepsin A
Helicobacter Infections
Helicobacter pylori
Gastrins
Acids
Duodenal Ulcer
Duodenal Diseases
Gastrin-Releasing Peptide
Gastrin-Secreting Cells
Peptic Ulcer
Ulcer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Long-term effects of Helicobacter pylori infection on acid and pepsin secretion. / Halter, F.; Zetterman, Rowen K.

In: Yale Journal of Biology and Medicine, Vol. 69, No. 1, 01.01.1996, p. 99-104.

Research output: Contribution to journalArticle

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