Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults

Nancy F. Crum-Cianflone, Kenneth Wilkins, Andrew W. Lee, Anthony Grosso, Michael L. Landrum, Amy Weintrob, Anuradha Ganesan, Jason Maguire, Stephanie Klopfer, Carolyn Brandt, William P. Bradley, Mark R. Wallace, Brian K. Agan, Susan Banks, Mary Bavaro, Helen Chun, Cathy Decker, Conner Eggleston, Susan Fraser, Heather HairstonJoshua Hartzell, Arthur Johnson, Mark Kortepeter, Tahaniyat Lalani, Alan Lifson, Michelle Linfesty, Grace Macalino, Scott Merritt, Barbara Nagaraj, Robert O'Connell, Jason Okulicz, Sheila Peel, Michael Polis, John Powers, Sybil Tasker, Timothy Whitman, Glenn Wortmann, Michael Zapor

Research output: Contribution to journalArticle

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Abstract

Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49% had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.

Original languageEnglish (US)
Pages (from-to)1815-1823
Number of pages9
JournalJournal of Infectious Diseases
Volume203
Issue number12
DOIs
StatePublished - Jun 15 2011

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Hepatitis A
Vaccination
HIV
Hepatitis A virus
Confidence Intervals
RNA
Vaccines
Hepatitis A Vaccines
Virus Diseases
CD4 Lymphocyte Count
Immunity
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Crum-Cianflone, N. F., Wilkins, K., Lee, A. W., Grosso, A., Landrum, M. L., Weintrob, A., ... Zapor, M. (2011). Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults. Journal of Infectious Diseases, 203(12), 1815-1823. https://doi.org/10.1093/infdis/jir180

Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults. / Crum-Cianflone, Nancy F.; Wilkins, Kenneth; Lee, Andrew W.; Grosso, Anthony; Landrum, Michael L.; Weintrob, Amy; Ganesan, Anuradha; Maguire, Jason; Klopfer, Stephanie; Brandt, Carolyn; Bradley, William P.; Wallace, Mark R.; Agan, Brian K.; Banks, Susan; Bavaro, Mary; Chun, Helen; Decker, Cathy; Eggleston, Conner; Fraser, Susan; Hairston, Heather; Hartzell, Joshua; Johnson, Arthur; Kortepeter, Mark; Lalani, Tahaniyat; Lifson, Alan; Linfesty, Michelle; Macalino, Grace; Merritt, Scott; Nagaraj, Barbara; O'Connell, Robert; Okulicz, Jason; Peel, Sheila; Polis, Michael; Powers, John; Tasker, Sybil; Whitman, Timothy; Wortmann, Glenn; Zapor, Michael.

In: Journal of Infectious Diseases, Vol. 203, No. 12, 15.06.2011, p. 1815-1823.

Research output: Contribution to journalArticle

Crum-Cianflone, NF, Wilkins, K, Lee, AW, Grosso, A, Landrum, ML, Weintrob, A, Ganesan, A, Maguire, J, Klopfer, S, Brandt, C, Bradley, WP, Wallace, MR, Agan, BK, Banks, S, Bavaro, M, Chun, H, Decker, C, Eggleston, C, Fraser, S, Hairston, H, Hartzell, J, Johnson, A, Kortepeter, M, Lalani, T, Lifson, A, Linfesty, M, Macalino, G, Merritt, S, Nagaraj, B, O'Connell, R, Okulicz, J, Peel, S, Polis, M, Powers, J, Tasker, S, Whitman, T, Wortmann, G & Zapor, M 2011, 'Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults', Journal of Infectious Diseases, vol. 203, no. 12, pp. 1815-1823. https://doi.org/10.1093/infdis/jir180
Crum-Cianflone NF, Wilkins K, Lee AW, Grosso A, Landrum ML, Weintrob A et al. Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults. Journal of Infectious Diseases. 2011 Jun 15;203(12):1815-1823. https://doi.org/10.1093/infdis/jir180
Crum-Cianflone, Nancy F. ; Wilkins, Kenneth ; Lee, Andrew W. ; Grosso, Anthony ; Landrum, Michael L. ; Weintrob, Amy ; Ganesan, Anuradha ; Maguire, Jason ; Klopfer, Stephanie ; Brandt, Carolyn ; Bradley, William P. ; Wallace, Mark R. ; Agan, Brian K. ; Banks, Susan ; Bavaro, Mary ; Chun, Helen ; Decker, Cathy ; Eggleston, Conner ; Fraser, Susan ; Hairston, Heather ; Hartzell, Joshua ; Johnson, Arthur ; Kortepeter, Mark ; Lalani, Tahaniyat ; Lifson, Alan ; Linfesty, Michelle ; Macalino, Grace ; Merritt, Scott ; Nagaraj, Barbara ; O'Connell, Robert ; Okulicz, Jason ; Peel, Sheila ; Polis, Michael ; Powers, John ; Tasker, Sybil ; Whitman, Timothy ; Wortmann, Glenn ; Zapor, Michael. / Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults. In: Journal of Infectious Diseases. 2011 ; Vol. 203, No. 12. pp. 1815-1823.
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abstract = "Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49{\%} had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89{\%} of HIV-infected adults (95{\%} confidence interval [CI], 83{\%}-94{\%}), compared with 100{\%} (95{\%} CI, 99{\%}-100{\%}) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90{\%} (104 of 116; 95{\%} CI, 83{\%}-95{\%}) remained seropositive at 3 years and 85{\%} (63 of 74; 95{\%} CI, 75{\%}-92{\%}) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.",
author = "Crum-Cianflone, {Nancy F.} and Kenneth Wilkins and Lee, {Andrew W.} and Anthony Grosso and Landrum, {Michael L.} and Amy Weintrob and Anuradha Ganesan and Jason Maguire and Stephanie Klopfer and Carolyn Brandt and Bradley, {William P.} and Wallace, {Mark R.} and Agan, {Brian K.} and Susan Banks and Mary Bavaro and Helen Chun and Cathy Decker and Conner Eggleston and Susan Fraser and Heather Hairston and Joshua Hartzell and Arthur Johnson and Mark Kortepeter and Tahaniyat Lalani and Alan Lifson and Michelle Linfesty and Grace Macalino and Scott Merritt and Barbara Nagaraj and Robert O'Connell and Jason Okulicz and Sheila Peel and Michael Polis and John Powers and Sybil Tasker and Timothy Whitman and Glenn Wortmann and Michael Zapor",
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T1 - Long-term durability of immune responses after hepatitis A vaccination among HIV-infected adults

AU - Crum-Cianflone, Nancy F.

AU - Wilkins, Kenneth

AU - Lee, Andrew W.

AU - Grosso, Anthony

AU - Landrum, Michael L.

AU - Weintrob, Amy

AU - Ganesan, Anuradha

AU - Maguire, Jason

AU - Klopfer, Stephanie

AU - Brandt, Carolyn

AU - Bradley, William P.

AU - Wallace, Mark R.

AU - Agan, Brian K.

AU - Banks, Susan

AU - Bavaro, Mary

AU - Chun, Helen

AU - Decker, Cathy

AU - Eggleston, Conner

AU - Fraser, Susan

AU - Hairston, Heather

AU - Hartzell, Joshua

AU - Johnson, Arthur

AU - Kortepeter, Mark

AU - Lalani, Tahaniyat

AU - Lifson, Alan

AU - Linfesty, Michelle

AU - Macalino, Grace

AU - Merritt, Scott

AU - Nagaraj, Barbara

AU - O'Connell, Robert

AU - Okulicz, Jason

AU - Peel, Sheila

AU - Polis, Michael

AU - Powers, John

AU - Tasker, Sybil

AU - Whitman, Timothy

AU - Wortmann, Glenn

AU - Zapor, Michael

PY - 2011/6/15

Y1 - 2011/6/15

N2 - Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49% had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.

AB - Background. Vaccination provides long-term immunity to hepatitis A virus (HAV) among the general population, but there are no such data regarding vaccine durability among human immunodeficiency virus (HIV) - infected adults. Methods. We retrospectively studied HIV-infected adults who had received 2 doses of HAV vaccine. We analyzed blood specimens taken at 1 year, 3 years, and, when available, 6-10 years postvaccination. HAV immunoglobulin G (IgG) values of ≥10 mIU/mL were considered seropositive. Results. We evaluated specimens from 130 HIV-infected adults with a median age of 35 years and a median CD4 cell count of 461 cells/mm3 at or before time of vaccination. Of these, 49% had an HIV RNA load <1000 copies/mL. Initial vaccine responses were achieved in 89% of HIV-infected adults (95% confidence interval [CI], 83%-94%), compared with 100% (95% CI, 99%-100%) of historical HIV-uninfected adults. Among initial HIV-infected responders with available specimens, 90% (104 of 116; 95% CI, 83%-95%) remained seropositive at 3 years and 85% (63 of 74; 95% CI, 75%-92%) at 6-10 years. Geometric mean concentrations (GMCs) among HIV-infected adults were 154, 111, and 64 mIU/mL at 1, 3, and 6-10 years, respectively, compared with 1734, 687, and 684 mIU/mL among HIV-uninfected persons. Higher GMCs over time among HIV-infected adults were associated with lower log10 HIV RNA levels (β = 2.12, P = .04). Conclusions. Most adults with well-controlled HIV infections had durable seropositive responses up to 6-10 years after HAV vaccination. Suppressed HIV RNA levels are associated with durable HAV responses.

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