Long term dose response study of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced urinary bladder carcinogenesis

Masayuki Arai, Margaret St John, Shoji Fukushima, Gilbert H. Friedell, Samuel Monroe Cohen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of dose was evaluated for the bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). The chemical was fed to male weanling F344 rats for 30 weeks followed by 74 weeks of control diet. The incidences of bladder carcinoma were 100, 100, 87, 0, 0 and 0% for doses of 0.2, 0.1, 0.05, 0.01, 0.005 and 0.001%, respectively. There was an inverse relationship between dose and latency period. There was no increased incidence of tumors of other tissues.

Original languageEnglish (US)
Pages (from-to)261-269
Number of pages9
JournalCancer Letters
Volume18
Issue number3
DOIs
StatePublished - Jan 1 1983

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FANFT
Carcinogenesis
Urinary Bladder
Incidence
Inbred F344 Rats
Diet
Carcinoma
Neoplasms
formamide

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Long term dose response study of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced urinary bladder carcinogenesis. / Arai, Masayuki; John, Margaret St; Fukushima, Shoji; Friedell, Gilbert H.; Cohen, Samuel Monroe.

In: Cancer Letters, Vol. 18, No. 3, 01.01.1983, p. 261-269.

Research output: Contribution to journalArticle

Arai, Masayuki ; John, Margaret St ; Fukushima, Shoji ; Friedell, Gilbert H. ; Cohen, Samuel Monroe. / Long term dose response study of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced urinary bladder carcinogenesis. In: Cancer Letters. 1983 ; Vol. 18, No. 3. pp. 261-269.
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