Long-term clinicopathological characteristics of alpacas naturally infected with bovine viral diarrhea virus type Ib

D. Bedenice, E. Dubovi, Clayton L Kelling, J. N. Henningson, C. L. Topliff, N. Parry

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Substantial bovine viral diarrhea virus (BVDV)-related production losses in North American alpaca herds have been associated with BVDV type Ib infection. Objectives: To classify and differentiate the long-term clinicopathological characteristics of BVDV type Ib infection of alpaca crias, after natural virus exposure. We hypothesized that persistently infected (PI) alpacas specifically demonstrate growth retardation, clinicopathological evidence of opportunistic infections, and early mortality. Animals: Thirty-five crias naturally exposed to BVDV (18 acute, 3 chronic, 14 PIs), and 19 healthy cohort controls of 5 northeastern alpaca farms were prospectively evaluated over 2 years (September 2005-September 2008). Methods: Observational cohort-control study. Results: Chronically (viremia >3 weeks) and PI crias demonstrated significantly lower birth weights, decreased growth rates, anemia, and monocytosis compared with control animals. Common clinical problems of PI alpacas included chronic wasting, diarrhea, and respiratory disease. Median survival of PI alpacas that died was 177 days (interquartile range, 555) with a case fatality rate of 50% within 6 months of life. Transplacental infection was confirmed in 82% (9/11) of pregnant females on 1 farm, resulting in the birth of 7 PI crias (7/10 deliveries; 1 animal was aborted). Mean gestation at the beginning and end of BVDV exposure was 64 and 114 days, respectively. Conclusions and Clinical Importance: Natural BVDV type 1b infection during early pregnancy resulted in a high incidence of PI offspring. Although PI alpacas may have distinct clinical characteristics, verification of persistent viremia in the absence of endogenous, neutralizing antibodies is essential to differentiate persistent from chronic infection.

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume25
Issue number3
DOIs
StatePublished - May 1 2011

Fingerprint

New World Camelids
Bovine Viral Diarrhea Viruses
alpacas
Bovine viral diarrhea virus
Virus Diseases
infection
Viremia
viremia
pregnancy
transplacental transmission
Pregnancy
farms
animals
Mortality
low birth weight
Opportunistic Infections
Growth
Infection
Neutralizing Antibodies
neutralizing antibodies

Keywords

  • Bovine viral diarrhea
  • Camelid
  • Persistent infection

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Long-term clinicopathological characteristics of alpacas naturally infected with bovine viral diarrhea virus type Ib. / Bedenice, D.; Dubovi, E.; Kelling, Clayton L; Henningson, J. N.; Topliff, C. L.; Parry, N.

In: Journal of Veterinary Internal Medicine, Vol. 25, No. 3, 01.05.2011, p. 605-612.

Research output: Contribution to journalArticle

Bedenice, D. ; Dubovi, E. ; Kelling, Clayton L ; Henningson, J. N. ; Topliff, C. L. ; Parry, N. / Long-term clinicopathological characteristics of alpacas naturally infected with bovine viral diarrhea virus type Ib. In: Journal of Veterinary Internal Medicine. 2011 ; Vol. 25, No. 3. pp. 605-612.
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abstract = "Background: Substantial bovine viral diarrhea virus (BVDV)-related production losses in North American alpaca herds have been associated with BVDV type Ib infection. Objectives: To classify and differentiate the long-term clinicopathological characteristics of BVDV type Ib infection of alpaca crias, after natural virus exposure. We hypothesized that persistently infected (PI) alpacas specifically demonstrate growth retardation, clinicopathological evidence of opportunistic infections, and early mortality. Animals: Thirty-five crias naturally exposed to BVDV (18 acute, 3 chronic, 14 PIs), and 19 healthy cohort controls of 5 northeastern alpaca farms were prospectively evaluated over 2 years (September 2005-September 2008). Methods: Observational cohort-control study. Results: Chronically (viremia >3 weeks) and PI crias demonstrated significantly lower birth weights, decreased growth rates, anemia, and monocytosis compared with control animals. Common clinical problems of PI alpacas included chronic wasting, diarrhea, and respiratory disease. Median survival of PI alpacas that died was 177 days (interquartile range, 555) with a case fatality rate of 50{\%} within 6 months of life. Transplacental infection was confirmed in 82{\%} (9/11) of pregnant females on 1 farm, resulting in the birth of 7 PI crias (7/10 deliveries; 1 animal was aborted). Mean gestation at the beginning and end of BVDV exposure was 64 and 114 days, respectively. Conclusions and Clinical Importance: Natural BVDV type 1b infection during early pregnancy resulted in a high incidence of PI offspring. Although PI alpacas may have distinct clinical characteristics, verification of persistent viremia in the absence of endogenous, neutralizing antibodies is essential to differentiate persistent from chronic infection.",
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