Long-term clinical outcome of coronary artery stenting in elderly patients

Vassilis A. Voudris, John S. Skoularigis, John S. Malakos, George C. Kourgianides, Gregory S. Pavlides, Athanasios N. Manginas, Genovefa D. Kolovou, Dennis V. Cokkinos

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The elderly constitute a rapidly expanding segment of our population and cardiovascular disease becomes more prevalent with increasing age. Existing data have shown that percutaneous coronary interventions in the elderly are associated with an increase risk of in-hospital complications compared to younger patients. In the present study we retrospectively assessed the long-term clinical outcome of coronary artery stenting in an elderly population and compared them with the cohort of younger patients. Methods: The study population included 402 consecutive patients with coronary artery disease who underwent coronary artery stenting; of these 69 were elderly (age > 70 years, group I) and 333 were younger (age ≤ 70 years, group II). Percutaneous coronary intervention combined with stent implantation was performed using standard techniques. Clinical outcomes during follow-up (24 ± 13 months, range 7-56 months) were obtained in all patients without major in-hospital complications. Survival curves and multivariate Cox proportional hazard models for any late clinical event were reported. Results: No difference in in-hospital complications or clinical success rate was observed between the two groups of patients. Complete revascularization was obtained more frequently in younger compared to elderly patients (P < 0.05). At 2 years, event-free survival was 62% in the elderly and 76% in younger patients (P < 0.001); this difference was mostly made-up by recurrence of angina in the elderly. Impaired left ventricular systolic function (ejection fraction < 40%) was an independent predictor of late death. Conclusions: Coronary artery stenting is an effective therapeutic strategy in elderly with coronary artery disease and is associated with good short- and longterm results. Age per se should not preclude patients from undergoing coronary stenting.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalCoronary Artery Disease
Volume13
Issue number6
DOIs
StatePublished - Sep 1 2002

Fingerprint

Coronary Vessels
Percutaneous Coronary Intervention
Coronary Artery Disease
Population
Left Ventricular Function
Proportional Hazards Models
Disease-Free Survival
Stents
Cardiovascular Diseases
Recurrence
Survival

Keywords

  • Coronary angioplasty
  • Coronary artery disease
  • Elderly
  • Stenting

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Voudris, V. A., Skoularigis, J. S., Malakos, J. S., Kourgianides, G. C., Pavlides, G. S., Manginas, A. N., ... Cokkinos, D. V. (2002). Long-term clinical outcome of coronary artery stenting in elderly patients. Coronary Artery Disease, 13(6), 323-329. https://doi.org/10.1097/00019501-200209000-00004

Long-term clinical outcome of coronary artery stenting in elderly patients. / Voudris, Vassilis A.; Skoularigis, John S.; Malakos, John S.; Kourgianides, George C.; Pavlides, Gregory S.; Manginas, Athanasios N.; Kolovou, Genovefa D.; Cokkinos, Dennis V.

In: Coronary Artery Disease, Vol. 13, No. 6, 01.09.2002, p. 323-329.

Research output: Contribution to journalArticle

Voudris, VA, Skoularigis, JS, Malakos, JS, Kourgianides, GC, Pavlides, GS, Manginas, AN, Kolovou, GD & Cokkinos, DV 2002, 'Long-term clinical outcome of coronary artery stenting in elderly patients', Coronary Artery Disease, vol. 13, no. 6, pp. 323-329. https://doi.org/10.1097/00019501-200209000-00004
Voudris VA, Skoularigis JS, Malakos JS, Kourgianides GC, Pavlides GS, Manginas AN et al. Long-term clinical outcome of coronary artery stenting in elderly patients. Coronary Artery Disease. 2002 Sep 1;13(6):323-329. https://doi.org/10.1097/00019501-200209000-00004
Voudris, Vassilis A. ; Skoularigis, John S. ; Malakos, John S. ; Kourgianides, George C. ; Pavlides, Gregory S. ; Manginas, Athanasios N. ; Kolovou, Genovefa D. ; Cokkinos, Dennis V. / Long-term clinical outcome of coronary artery stenting in elderly patients. In: Coronary Artery Disease. 2002 ; Vol. 13, No. 6. pp. 323-329.
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abstract = "Background: The elderly constitute a rapidly expanding segment of our population and cardiovascular disease becomes more prevalent with increasing age. Existing data have shown that percutaneous coronary interventions in the elderly are associated with an increase risk of in-hospital complications compared to younger patients. In the present study we retrospectively assessed the long-term clinical outcome of coronary artery stenting in an elderly population and compared them with the cohort of younger patients. Methods: The study population included 402 consecutive patients with coronary artery disease who underwent coronary artery stenting; of these 69 were elderly (age > 70 years, group I) and 333 were younger (age ≤ 70 years, group II). Percutaneous coronary intervention combined with stent implantation was performed using standard techniques. Clinical outcomes during follow-up (24 ± 13 months, range 7-56 months) were obtained in all patients without major in-hospital complications. Survival curves and multivariate Cox proportional hazard models for any late clinical event were reported. Results: No difference in in-hospital complications or clinical success rate was observed between the two groups of patients. Complete revascularization was obtained more frequently in younger compared to elderly patients (P < 0.05). At 2 years, event-free survival was 62{\%} in the elderly and 76{\%} in younger patients (P < 0.001); this difference was mostly made-up by recurrence of angina in the elderly. Impaired left ventricular systolic function (ejection fraction < 40{\%}) was an independent predictor of late death. Conclusions: Coronary artery stenting is an effective therapeutic strategy in elderly with coronary artery disease and is associated with good short- and longterm results. Age per se should not preclude patients from undergoing coronary stenting.",
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AU - Skoularigis, John S.

AU - Malakos, John S.

AU - Kourgianides, George C.

AU - Pavlides, Gregory S.

AU - Manginas, Athanasios N.

AU - Kolovou, Genovefa D.

AU - Cokkinos, Dennis V.

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N2 - Background: The elderly constitute a rapidly expanding segment of our population and cardiovascular disease becomes more prevalent with increasing age. Existing data have shown that percutaneous coronary interventions in the elderly are associated with an increase risk of in-hospital complications compared to younger patients. In the present study we retrospectively assessed the long-term clinical outcome of coronary artery stenting in an elderly population and compared them with the cohort of younger patients. Methods: The study population included 402 consecutive patients with coronary artery disease who underwent coronary artery stenting; of these 69 were elderly (age > 70 years, group I) and 333 were younger (age ≤ 70 years, group II). Percutaneous coronary intervention combined with stent implantation was performed using standard techniques. Clinical outcomes during follow-up (24 ± 13 months, range 7-56 months) were obtained in all patients without major in-hospital complications. Survival curves and multivariate Cox proportional hazard models for any late clinical event were reported. Results: No difference in in-hospital complications or clinical success rate was observed between the two groups of patients. Complete revascularization was obtained more frequently in younger compared to elderly patients (P < 0.05). At 2 years, event-free survival was 62% in the elderly and 76% in younger patients (P < 0.001); this difference was mostly made-up by recurrence of angina in the elderly. Impaired left ventricular systolic function (ejection fraction < 40%) was an independent predictor of late death. Conclusions: Coronary artery stenting is an effective therapeutic strategy in elderly with coronary artery disease and is associated with good short- and longterm results. Age per se should not preclude patients from undergoing coronary stenting.

AB - Background: The elderly constitute a rapidly expanding segment of our population and cardiovascular disease becomes more prevalent with increasing age. Existing data have shown that percutaneous coronary interventions in the elderly are associated with an increase risk of in-hospital complications compared to younger patients. In the present study we retrospectively assessed the long-term clinical outcome of coronary artery stenting in an elderly population and compared them with the cohort of younger patients. Methods: The study population included 402 consecutive patients with coronary artery disease who underwent coronary artery stenting; of these 69 were elderly (age > 70 years, group I) and 333 were younger (age ≤ 70 years, group II). Percutaneous coronary intervention combined with stent implantation was performed using standard techniques. Clinical outcomes during follow-up (24 ± 13 months, range 7-56 months) were obtained in all patients without major in-hospital complications. Survival curves and multivariate Cox proportional hazard models for any late clinical event were reported. Results: No difference in in-hospital complications or clinical success rate was observed between the two groups of patients. Complete revascularization was obtained more frequently in younger compared to elderly patients (P < 0.05). At 2 years, event-free survival was 62% in the elderly and 76% in younger patients (P < 0.001); this difference was mostly made-up by recurrence of angina in the elderly. Impaired left ventricular systolic function (ejection fraction < 40%) was an independent predictor of late death. Conclusions: Coronary artery stenting is an effective therapeutic strategy in elderly with coronary artery disease and is associated with good short- and longterm results. Age per se should not preclude patients from undergoing coronary stenting.

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