Long-range restriction enzyme maps of DNF15S2, D3S2, and c-raf1 loci on the short arm of human chromosome 3

Ferenc Boldog, Rikard Erlandsson, George Klein, Janos Sumegi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Physical maps have been constructed around loci DNF15S2, D3S2, and c-raf1 on the short arm of human chromosome 3 using pulsed field gradient gel electrophoresis. The normal restriction pattern has not been altered by a t(3;8)(p14.2;q24.1) characteristic for a hereditary form of renal cell carcinoma, indicating that the breakpoint itself is not included in any of the mapped areas. We have found a CpG island within the DNF15S2 locus, suggesting the presence of a functional gene in the region.

Original languageEnglish (US)
Pages (from-to)295-306
Number of pages12
JournalCancer Genetics and Cytogenetics
Volume42
Issue number2
DOIs
StatePublished - Oct 15 1989

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CpG Islands
Chromosomes, Human, Pair 3
Pulsed Field Gel Electrophoresis
Human Chromosomes
Renal Cell Carcinoma
Enzymes
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Long-range restriction enzyme maps of DNF15S2, D3S2, and c-raf1 loci on the short arm of human chromosome 3. / Boldog, Ferenc; Erlandsson, Rikard; Klein, George; Sumegi, Janos.

In: Cancer Genetics and Cytogenetics, Vol. 42, No. 2, 15.10.1989, p. 295-306.

Research output: Contribution to journalArticle

Boldog, Ferenc ; Erlandsson, Rikard ; Klein, George ; Sumegi, Janos. / Long-range restriction enzyme maps of DNF15S2, D3S2, and c-raf1 loci on the short arm of human chromosome 3. In: Cancer Genetics and Cytogenetics. 1989 ; Vol. 42, No. 2. pp. 295-306.
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