Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

Shruti Mishra, Sumit S. Verma, Vipin Rai, Nikee Awasthee, Srinivas Chava, Kam Man Hui, Alan Prem Kumar, Kishore B. Challagundla, Gautam Sethi, Subash C. Gupta

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases. Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small molecule inhibitors have been used for the therapeutic targeting of lncRNAs. During the last decade, phytochemicals and nutraceuticals have been explored for their potential against lncRNAs. The common lncRNAs known to be modulated by phytochemicals include ROR, PVT1, HOTAIR, MALAT1, H19, MEG3, PCAT29, PANDAR, NEAT1, and GAS5. The phytochemicals such as curcumin, resveratrol, sulforaphane, berberine, EGCG, and gambogic acid have been examined against lncRNAs. In some cases, formulation of phytochemicals has also been used. The disease models where phytochemicals have been demonstrated to modulate lncRNAs expression include cancer, rheumatoid arthritis, osteoarthritis, and nonalcoholic fatty liver disease. The regulation of lncRNAs by phytochemicals can affect multi-steps of tumor development. When administered in combination with the conventional drugs, phytochemicals can also produce synergistic effects on lncRNAs leading to the sensitization of cancer cells. Phytochemicals target lncRNAs either directly or indirectly by affecting a wide variety of upstream molecules. However, the potential of phytochemicals against lncRNAs has been demonstrated mostly by preclinical studies in cancer models. How the modulation of lncRNAs by phytochemicals produce therapeutic effects on cancer and other chronic diseases is discussed in this review.

Original languageEnglish (US)
JournalCellular and Molecular Life Sciences
DOIs
StatePublished - Jan 1 2019

Fingerprint

Long Noncoding RNA
Phytochemicals
Chronic Disease
Neoplasms
Berberine
Curcumin
Antisense Oligonucleotides
Therapeutic Uses
Dietary Supplements
RNA Interference
Osteoarthritis
Rheumatoid Arthritis

Keywords

  • Chemosensitization
  • Non-coding RNA
  • Nutraceutical
  • Therapy
  • Tumor

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. / Mishra, Shruti; Verma, Sumit S.; Rai, Vipin; Awasthee, Nikee; Chava, Srinivas; Hui, Kam Man; Kumar, Alan Prem; Challagundla, Kishore B.; Sethi, Gautam; Gupta, Subash C.

In: Cellular and Molecular Life Sciences, 01.01.2019.

Research output: Contribution to journalReview article

Mishra, Shruti ; Verma, Sumit S. ; Rai, Vipin ; Awasthee, Nikee ; Chava, Srinivas ; Hui, Kam Man ; Kumar, Alan Prem ; Challagundla, Kishore B. ; Sethi, Gautam ; Gupta, Subash C. / Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. In: Cellular and Molecular Life Sciences. 2019.
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abstract = "The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases. Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small molecule inhibitors have been used for the therapeutic targeting of lncRNAs. During the last decade, phytochemicals and nutraceuticals have been explored for their potential against lncRNAs. The common lncRNAs known to be modulated by phytochemicals include ROR, PVT1, HOTAIR, MALAT1, H19, MEG3, PCAT29, PANDAR, NEAT1, and GAS5. The phytochemicals such as curcumin, resveratrol, sulforaphane, berberine, EGCG, and gambogic acid have been examined against lncRNAs. In some cases, formulation of phytochemicals has also been used. The disease models where phytochemicals have been demonstrated to modulate lncRNAs expression include cancer, rheumatoid arthritis, osteoarthritis, and nonalcoholic fatty liver disease. The regulation of lncRNAs by phytochemicals can affect multi-steps of tumor development. When administered in combination with the conventional drugs, phytochemicals can also produce synergistic effects on lncRNAs leading to the sensitization of cancer cells. Phytochemicals target lncRNAs either directly or indirectly by affecting a wide variety of upstream molecules. However, the potential of phytochemicals against lncRNAs has been demonstrated mostly by preclinical studies in cancer models. How the modulation of lncRNAs by phytochemicals produce therapeutic effects on cancer and other chronic diseases is discussed in this review.",
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AU - Hui, Kam Man

AU - Kumar, Alan Prem

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