Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases

Subash C. Gupta, Nikee Awasthee, Vipin Rai, Srinivas Chava, Venugopal Gunda, Kishore B. Challagundla

Research output: Contribution to journalReview article

Abstract

The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-κB signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NF-κB related lncRNAs can affect gene expression without modulating NF-κB signaling. Most of the lncRNAs with a potential to modulate NF-κB signaling are regulated by NF-κB itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions. The manner in which lncRNA and NF-κB crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed.

Original languageEnglish (US)
Article number188316
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1873
Issue number1
DOIs
StatePublished - Jan 2020

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Long Noncoding RNA
Neoplasms
Mucocutaneous Lymph Node Syndrome
Cerebral Infarction
Celiac Disease
Human Genome
MicroRNAs
Cardiomyopathies
Chronic Renal Insufficiency
Rheumatoid Arthritis
Diabetes Mellitus
Transcription Factors
Gene Expression
Pregnancy
Therapeutics

Keywords

  • Cancer
  • Chronic disease
  • LncRNA
  • NF-κB
  • Non-coding RNA

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. / Gupta, Subash C.; Awasthee, Nikee; Rai, Vipin; Chava, Srinivas; Gunda, Venugopal; Challagundla, Kishore B.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1873, No. 1, 188316, 01.2020.

Research output: Contribution to journalReview article

Gupta, Subash C. ; Awasthee, Nikee ; Rai, Vipin ; Chava, Srinivas ; Gunda, Venugopal ; Challagundla, Kishore B. / Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. In: Biochimica et Biophysica Acta - Reviews on Cancer. 2020 ; Vol. 1873, No. 1.
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