Long-lived ames dwarf mice are resistant to chemical stressors

Alex F. Bokov, Merry L. Lindsey, Christina Khodr, Marian R. Sabia, Arlan Richardson

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F 2-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.

Original languageEnglish (US)
Pages (from-to)819-827
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number8
DOIs
StatePublished - Aug 1 2009

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Keywords

  • Ames dwarf mice
  • Diquat
  • Liver
  • Paraquat
  • Reactive oxygen species

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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