Locoregional strategies for colorectal hepatic metastases

Michael O. Meyers, Aaron R. Sasson, Elin R. Sigurdson

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Hepatic colorectal metastases present a challenging problem in patients with recurrent colorectal cancer. Twenty percent of patients with recurrence will have liver metastases as a component of their disease, and only 10% of these patients will have isolated liver metastases that are resectable. Although systemic chemotherapy alone has not proven efficacious in the treatment of liver metastases, a number of options exist in managing these lesions. For those that are resectable, surgery remains the optimal treatment, with an expected 5-year survival rate of 33%-39% based on several large series. Hepatic artery chemotherapy is another adjunct treatment in patients undergoing resection and may further improve survival. This benefit may be even more pronounced when combined with systemic chemotherapy. Newer-generation agents are likely to further improve results. More recently, new therapeutic modalities have been used to treat unresectable lesions. These include hepatic artery chemotherapy and ablative techniques such as radiofrequency ablation and cryoablation. This article will highlight the data regarding hepatic resection for colorectal metastases, describe the rationale for and efficacy of hepatic arterial chemotherapy in the postoperative adjuvant setting and in unresectable liver disease, and review the current literature describing ablative techniques in the treatment of liver metastases.

Original languageEnglish (US)
Pages (from-to)34-44
Number of pages11
JournalClinical Colorectal Cancer
Volume3
Issue number1
DOIs
Publication statusPublished - May 2003

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Keywords

  • Cryoablation
  • Hepatic artery chemotherapy
  • Hepatic resection
  • Liver
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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