Locomotion and conditioned place preference produced by acute intravenous amphetamine: Role of dopamine receptors and individual differences in amphetamine self-administration

M. T. Bardo, J. M. Valone, Rick A Bevins

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on singletrial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1-3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both effects of amphetamine were completely blocked by pretreating rats with the D1 DA antagonist SCH-23390 (0.025 and 0.25 mg/kg) or the D2 DA antagonist eticlopride (0.2 and 2 mg/kg) on the conditioning trial. In a final experiment, single-trial amphetamine CPP did not predict subsequent self-administration of IV amphetamine (10-50 μg/infusion) using either a fixed ratio (FR) 1 or progressive ratio (PR) schedule of reinforcement. Thus, while sharing a similar DA receptor mechanism, the present results indicate that single-trial CPP and self- administration are dissociable effects of IV amphetamine.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalPsychopharmacology
Volume143
Issue number1
DOIs
StatePublished - May 3 1999

Fingerprint

Self Administration
Dopamine Receptors
Amphetamine
Locomotion
Individuality
Dopamine Antagonists
eticlopride
Catheters
Reinforcement Schedule
Reward
Intravenous Injections
Neck
Animal Models

Keywords

  • Amphetamine
  • Conditioned place preference
  • Dopamine
  • Dopamine receptor
  • Locomotor activity
  • Self administration

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on singletrial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1-3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both effects of amphetamine were completely blocked by pretreating rats with the D1 DA antagonist SCH-23390 (0.025 and 0.25 mg/kg) or the D2 DA antagonist eticlopride (0.2 and 2 mg/kg) on the conditioning trial. In a final experiment, single-trial amphetamine CPP did not predict subsequent self-administration of IV amphetamine (10-50 μg/infusion) using either a fixed ratio (FR) 1 or progressive ratio (PR) schedule of reinforcement. Thus, while sharing a similar DA receptor mechanism, the present results indicate that single-trial CPP and self- administration are dissociable effects of IV amphetamine.",
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