Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion

D. L. Rothman, A. M. Howseman, G. D. Graham, O. A.C. Petroff, G. Lantos, P. B. Fayad, L. M. Brass, G. I. Shulman, R. G. Shulman, J. W. Prichard

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

To assess whether elevated lactate in stable stroke is being actively produced from blood glucose localized 1H NMR stimulated echo spectra were obtained from a patient in the region of a 32‐day‐old cortical infarct before and 60–100 min after infusion of [1‐13C]glucose. Prior to the infusion the spectrum from the region of the infarct contained an elevated resonance from C3 lactate and a greatly reduced resonance from N‐acetyl groups relative to an unaffected contralateral region. After the infusion two additional resonances were observed at 62 and −64 Hz relative to the unlabeled resonance of C3 lactate which were assigned on the basis of chemical shift and relative intensity to[3‐13C]lactate. The [3‐13C]lactate fractional enrichment in the infarct region was measured to be 32% which is within error one‐half the average [1‐13C]plasma glucose enrichment during the postinfusion NMR measurement. The result suggests that the stroke lactate pool was completely derived from infused glucose. © 1991 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)302-307
Number of pages6
JournalMagnetic Resonance in Medicine
Volume21
Issue number2
DOIs
StatePublished - Oct 1991

Fingerprint

Protons
Lactic Acid
Stroke
Observation
Glucose
Blood Glucose

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Rothman, D. L., Howseman, A. M., Graham, G. D., Petroff, O. A. C., Lantos, G., Fayad, P. B., ... Prichard, J. W. (1991). Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion. Magnetic Resonance in Medicine, 21(2), 302-307. https://doi.org/10.1002/mrm.1910210215

Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion. / Rothman, D. L.; Howseman, A. M.; Graham, G. D.; Petroff, O. A.C.; Lantos, G.; Fayad, P. B.; Brass, L. M.; Shulman, G. I.; Shulman, R. G.; Prichard, J. W.

In: Magnetic Resonance in Medicine, Vol. 21, No. 2, 10.1991, p. 302-307.

Research output: Contribution to journalArticle

Rothman, DL, Howseman, AM, Graham, GD, Petroff, OAC, Lantos, G, Fayad, PB, Brass, LM, Shulman, GI, Shulman, RG & Prichard, JW 1991, 'Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion', Magnetic Resonance in Medicine, vol. 21, no. 2, pp. 302-307. https://doi.org/10.1002/mrm.1910210215
Rothman, D. L. ; Howseman, A. M. ; Graham, G. D. ; Petroff, O. A.C. ; Lantos, G. ; Fayad, P. B. ; Brass, L. M. ; Shulman, G. I. ; Shulman, R. G. ; Prichard, J. W. / Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion. In: Magnetic Resonance in Medicine. 1991 ; Vol. 21, No. 2. pp. 302-307.
@article{9ea508d090544ae39f03c6e9c9eda409,
title = "Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion",
abstract = "To assess whether elevated lactate in stable stroke is being actively produced from blood glucose localized 1H NMR stimulated echo spectra were obtained from a patient in the region of a 32‐day‐old cortical infarct before and 60–100 min after infusion of [1‐13C]glucose. Prior to the infusion the spectrum from the region of the infarct contained an elevated resonance from C3 lactate and a greatly reduced resonance from N‐acetyl groups relative to an unaffected contralateral region. After the infusion two additional resonances were observed at 62 and −64 Hz relative to the unlabeled resonance of C3 lactate which were assigned on the basis of chemical shift and relative intensity to[3‐13C]lactate. The [3‐13C]lactate fractional enrichment in the infarct region was measured to be 32{\%} which is within error one‐half the average [1‐13C]plasma glucose enrichment during the postinfusion NMR measurement. The result suggests that the stroke lactate pool was completely derived from infused glucose. {\circledC} 1991 Academic Press, Inc.",
author = "Rothman, {D. L.} and Howseman, {A. M.} and Graham, {G. D.} and Petroff, {O. A.C.} and G. Lantos and Fayad, {P. B.} and Brass, {L. M.} and Shulman, {G. I.} and Shulman, {R. G.} and Prichard, {J. W.}",
year = "1991",
month = "10",
doi = "10.1002/mrm.1910210215",
language = "English (US)",
volume = "21",
pages = "302--307",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Localized proton NMR observation of [3‐13C] lactate in stroke after [1‐13C] glucose infusion

AU - Rothman, D. L.

AU - Howseman, A. M.

AU - Graham, G. D.

AU - Petroff, O. A.C.

AU - Lantos, G.

AU - Fayad, P. B.

AU - Brass, L. M.

AU - Shulman, G. I.

AU - Shulman, R. G.

AU - Prichard, J. W.

PY - 1991/10

Y1 - 1991/10

N2 - To assess whether elevated lactate in stable stroke is being actively produced from blood glucose localized 1H NMR stimulated echo spectra were obtained from a patient in the region of a 32‐day‐old cortical infarct before and 60–100 min after infusion of [1‐13C]glucose. Prior to the infusion the spectrum from the region of the infarct contained an elevated resonance from C3 lactate and a greatly reduced resonance from N‐acetyl groups relative to an unaffected contralateral region. After the infusion two additional resonances were observed at 62 and −64 Hz relative to the unlabeled resonance of C3 lactate which were assigned on the basis of chemical shift and relative intensity to[3‐13C]lactate. The [3‐13C]lactate fractional enrichment in the infarct region was measured to be 32% which is within error one‐half the average [1‐13C]plasma glucose enrichment during the postinfusion NMR measurement. The result suggests that the stroke lactate pool was completely derived from infused glucose. © 1991 Academic Press, Inc.

AB - To assess whether elevated lactate in stable stroke is being actively produced from blood glucose localized 1H NMR stimulated echo spectra were obtained from a patient in the region of a 32‐day‐old cortical infarct before and 60–100 min after infusion of [1‐13C]glucose. Prior to the infusion the spectrum from the region of the infarct contained an elevated resonance from C3 lactate and a greatly reduced resonance from N‐acetyl groups relative to an unaffected contralateral region. After the infusion two additional resonances were observed at 62 and −64 Hz relative to the unlabeled resonance of C3 lactate which were assigned on the basis of chemical shift and relative intensity to[3‐13C]lactate. The [3‐13C]lactate fractional enrichment in the infarct region was measured to be 32% which is within error one‐half the average [1‐13C]plasma glucose enrichment during the postinfusion NMR measurement. The result suggests that the stroke lactate pool was completely derived from infused glucose. © 1991 Academic Press, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0026005502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026005502&partnerID=8YFLogxK

U2 - 10.1002/mrm.1910210215

DO - 10.1002/mrm.1910210215

M3 - Article

C2 - 1745129

AN - SCOPUS:0026005502

VL - 21

SP - 302

EP - 307

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -