Localized Orbital Rhabdomyosarcoma: An Interim Report of the Intergroup Rhabdomyosarcoma Study Committee

Moody Wharam, Mohan Beltangady, Daniel Hays, Ruth Heyn, Abdel Ragab, Edward Soule, Melvin Tefft, Harold Maurer

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Abstract

Children with rhabdomyosarcoma (RMS) (1461 total cases) were included in two prospective, randomized protocols conducted by the Intergroup Rhabdomyosarcoma Study (IRS) Committee from November 1972 to June 1983. Treatment assignment was determined by extent of tumor at diagnosis (clinicopathologic group) and not by primary site. Accordingly, 127 patients with RIVIS confined to the region of the eyelid and orbit were treated by a variety of regimens characterized by initial partial tumor resection followed by concurrent multiagent chemotherapy and orbital radiation therapy. Recurrent tumor developed in ten patients. Seven relapsed initially in the orbit (of whom 4 were salvaged) and three in regional nodes. In addition to the six patients who died of tumor, three died of other causes for a 93% 3-year actuarial survival rate. In 89 children who had subtotal resection or biopsy only, the local control rate with radiotherapy and chemotherapy was 94%.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalOphthalmology
Volume94
Issue number3
DOIs
StatePublished - Jan 1 1987

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Rhabdomyosarcoma
Orbit
Neoplasms
Radiotherapy
Drug Therapy
Eyelids
Survival Rate
Biopsy
Therapeutics

Keywords

  • orbital rhabdomyosarcoma
  • orbital tumors
  • pediatric tumors

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wharam, M., Beltangady, M., Hays, D., Heyn, R., Ragab, A., Soule, E., ... Maurer, H. (1987). Localized Orbital Rhabdomyosarcoma: An Interim Report of the Intergroup Rhabdomyosarcoma Study Committee. Ophthalmology, 94(3), 251-254. https://doi.org/10.1016/S0161-6420(87)33464-5

Localized Orbital Rhabdomyosarcoma : An Interim Report of the Intergroup Rhabdomyosarcoma Study Committee. / Wharam, Moody; Beltangady, Mohan; Hays, Daniel; Heyn, Ruth; Ragab, Abdel; Soule, Edward; Tefft, Melvin; Maurer, Harold.

In: Ophthalmology, Vol. 94, No. 3, 01.01.1987, p. 251-254.

Research output: Contribution to journalArticle

Wharam, M, Beltangady, M, Hays, D, Heyn, R, Ragab, A, Soule, E, Tefft, M & Maurer, H 1987, 'Localized Orbital Rhabdomyosarcoma: An Interim Report of the Intergroup Rhabdomyosarcoma Study Committee', Ophthalmology, vol. 94, no. 3, pp. 251-254. https://doi.org/10.1016/S0161-6420(87)33464-5
Wharam, Moody ; Beltangady, Mohan ; Hays, Daniel ; Heyn, Ruth ; Ragab, Abdel ; Soule, Edward ; Tefft, Melvin ; Maurer, Harold. / Localized Orbital Rhabdomyosarcoma : An Interim Report of the Intergroup Rhabdomyosarcoma Study Committee. In: Ophthalmology. 1987 ; Vol. 94, No. 3. pp. 251-254.
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