Localization of the inositol 1,4,5-trisphosphate receptor in synaptic terminals in the vertebrate retina

Y. W. Peng, A. H. Sharp, S. H. Snyder, K. W. Yau

Research output: Contribution to journalArticle

91 Scopus citations


Inositol 1,4,5-trisphosphate (InsP3) mobilizes internal Ca2+ in cells by binding to a receptor protein, which has recently been purified and molecularly cloned. To clarify those neuronal functions that are regulated by InsP3, we have localized this (InsP3) receptor protein immunocytochemically in the retina, a neural tissue of well-defined structure and function. Positive staining in neurons is confined almost exclusively to the synaptic layers. Using dissociated retinal neurons, we have further localized the receptor to presynaptic terminals of photoreceptors and bipolar cells, as well as the synaptic processes of amacrine cells. The specific association of InsP3 receptors with synaptic terminals suggests a role for InsP3 in synaptic modulation, especially with respect to transmitter release.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
Issue number4
Publication statusPublished - Apr 1991


ASJC Scopus subject areas

  • Neuroscience(all)

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