Localization of the central pressor action of bradykinin to the cerebral third ventricle.

R. E. Lewis, M. I. Phillips

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bradykinin injected into the lateral ventricle produces a rise in blood pressure. Cream plugs selectively localized to discrete regions of the ventricular system were used to block drug access to periventricular sites. Third ventricular plugs blocked the pressor response to lateral ventricular injections of 5 micrograms bradykinin (27 +/- 5 before vs. 5 +/- 5 mmHg after plug, n = 7) and 100 ng angiotensin II (22 +/- 3 before vs. 4 +/- 2 mmHg after plug, n = 5). Third ventricular plugs also suppressed the drinking response to angiotensin II (3.7 +/- 0.6 before vs. 0.9 +/- 0.6 ml after plug, n = 5). However, plugs that occluded the fourth ventricle failed to suppress the central bradykinin pressor response (27 +/- 8 before vs. 35 +/- 9 mmHg after plug, n = 5). The data suggest that the central bradykinin pressor response has a site of action similar to that of angiotensin II in the ventral third ventricle.

Original languageEnglish (US)
Pages (from-to)R63-68
JournalThe American journal of physiology
Volume247
Issue number1 Pt 2
StatePublished - Jul 1 1984

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Cerebral Ventricles
Third Ventricle
Bradykinin
Angiotensin II
Fourth Ventricle
Lateral Ventricles
Drinking
Blood Pressure
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Localization of the central pressor action of bradykinin to the cerebral third ventricle. / Lewis, R. E.; Phillips, M. I.

In: The American journal of physiology, Vol. 247, No. 1 Pt 2, 01.07.1984, p. R63-68.

Research output: Contribution to journalArticle

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