Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation

W. J. Kimberling, T. Fulbeck, L. Dixon, H. A. Lubs

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Significant linkage was found between spherocytosis and a translocation involving the short arms of chromosomes 8 and 12. The gene for spherocytosis, therefore, is likely either very close to the centromere of chromosome 8 or on 12p. The unusually high frequency of spontaneous abortion in this family was probably due to this translocation and was unrelated to the spherocytosis.

Original languageEnglish (US)
Pages (from-to)586-594
Number of pages9
JournalAmerican Journal of Human Genetics
Volume27
Issue number5
StatePublished - Dec 1 1975

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Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 8
Centromere
Spontaneous Abortion
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Localization of spherocytosis to chromosome 8 or 12 and report of a family with spherocytosis and a reciprocal translocation. / Kimberling, W. J.; Fulbeck, T.; Dixon, L.; Lubs, H. A.

In: American Journal of Human Genetics, Vol. 27, No. 5, 01.12.1975, p. 586-594.

Research output: Contribution to journalArticle

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