Localization of sequences within the latency-related gene of bovine herpesvirus 1 that inhibit mammalian cell growth

Vicki Geiser, Clinton J Jones

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth inhibitory function of the LR gene maps to a 463-bp XbaI-PstI fragment. Introduction of stop codons into the XbaI-PstI fragment had no effect on inhibiting growth. Expression of a LR strand-specific transcript correlates with growth inhibition in bovine fibroblasts and mouse neuroblastoma cells.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalJournal of neurovirology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2005

Fingerprint

Bovine Herpesvirus 1
Growth
Genes
Terminator Codon
Sensory Receptor Cells
Neuroblastoma
Fibroblasts
RNA
Apoptosis
Viruses

Keywords

  • Bovine herpesvirus 1
  • Cell growth
  • Latency-related gene

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Localization of sequences within the latency-related gene of bovine herpesvirus 1 that inhibit mammalian cell growth. / Geiser, Vicki; Jones, Clinton J.

In: Journal of neurovirology, Vol. 11, No. 6, 01.12.2005, p. 563-570.

Research output: Contribution to journalArticle

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