Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain

Kevin J. Anderson, Daniel T. Monaghan, Charles B. Cangro, M. A A Namboodiri, Joseph H. Neale, Carl W. Cotman

Research output: Contribution to journalArticle

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Abstract

N-acetylaspartylglutamate (NAAG) was detected immunohistochemically in the rat brain using an antiserum which recognizes carbodiimide-fixed NAAG. NAAG-like immunoreactivity is described in 5 areas of the brain; olfactory bulb, septal nuclear area, lateral geniculate nucleus, superior colliculus and the entorhinal cortex/hippocampal formation. Mitral cells of the olfactory bulb and neurons concentrated in the medial septum were densely immunostained. A dense population of immunoreactive puncta was found in the superior colliculus and lateral geniculate nucleus (LGN). The LGN also contained immunoreactive neurons. The entorhinal cortex contained numerous immunoreactive cells in layers II-III while the hippocampus had few neurons that were NAAG-positive.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalNeuroscience Letters
Volume72
Issue number1
DOIs
StatePublished - Dec 3 1986

Fingerprint

Geniculate Bodies
Entorhinal Cortex
Superior Colliculi
Olfactory Bulb
Brain
Neurons
Hippocampus
Septum of Brain
Carbodiimides
Immune Sera
N-acetyl-1-aspartylglutamic acid
Population

Keywords

  • Aspartate
  • Dipeptide
  • Glutamate
  • Immunohistochemistry
  • N-Acetylaspartylglutamate (NAAG)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain. / Anderson, Kevin J.; Monaghan, Daniel T.; Cangro, Charles B.; Namboodiri, M. A A; Neale, Joseph H.; Cotman, Carl W.

In: Neuroscience Letters, Vol. 72, No. 1, 03.12.1986, p. 14-20.

Research output: Contribution to journalArticle

Anderson, Kevin J. ; Monaghan, Daniel T. ; Cangro, Charles B. ; Namboodiri, M. A A ; Neale, Joseph H. ; Cotman, Carl W. / Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain. In: Neuroscience Letters. 1986 ; Vol. 72, No. 1. pp. 14-20.
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