Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain

Jyotsna Pandey, Karen A Gould, Rodney D McComb, James D. Shull, Douglas L. Wendell

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Abstract

In some rat strains chronic administration of exogenous estrogens induces pyometritis, an inflammation of the uterus associated with infection, suggesting that there is genetic variation in susceptibility to estrogen-induced inflammation and pyometritis. In this article we report that following 10 weeks of treatment with the synthetic estrogen diethylstilbestrol (DES), Fisher 344 (F344) rats exhibit modest uterine inflammation and a 0% incidence of pyometritis. By contrast, under identical experimental conditions, Brown Norway (BN) rats exhibit significant inflammation and a 100% incidence of pyometritis. Similarly, we also observed profound uterine inflammation and a 100% incidence of pyometritis in a congenic rat strain in which a segment of RNO5 from the BN strain is carried on the F344 strain. These data suggest that a locus on RNO5 controls both the magnitude of DES-induced uterine inflammation and susceptibility to DES-induced pyometritis. This locus, designated Eutr2, resides within the same segment of RNO5 as the Eutr1 locus, which confers susceptibility to E2-induced pyometritis in an F2 population generated in a cross between the BN and August × Copenhagen 9935, Irish (ACI) strains.

Original languageEnglish (US)
Pages (from-to)865-872
Number of pages8
JournalMammalian Genome
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2005

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Diethylstilbestrol
Inflammation
Norway
Incidence
Estrogens
Estradiol Congeners
Uterus
Infection
Population

ASJC Scopus subject areas

  • Genetics

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Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain. / Pandey, Jyotsna; Gould, Karen A; McComb, Rodney D; Shull, James D.; Wendell, Douglas L.

In: Mammalian Genome, Vol. 16, No. 11, 01.11.2005, p. 865-872.

Research output: Contribution to journalArticle

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