Local minocycline effect on inflammation and clinical attachment during periodontal maintenance: Randomized clinical trial

Amy C Killeen, Jennifer A. Harn, Leah M. Erickson, Fang Yu, Richard A Reinhardt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Minocycline microspheres (MMs) are being used to treat residual inflamed periodontal pockets during periodontal maintenance therapy (PMT), but evidence for efficacy from randomized clinical trials is lacking. The purpose of this study is to evaluate the effect of MMs plus scaling and root planing (SRP) on these sites. Methods: Sixty patients with chronic periodontitis on 6- month PMT intervals to be followed for 1 year were randomized (51 completed the study) into two statistically similar groups, SRP + MM (aged 66.8 years) and SRP alone (aged 67 years), to treat a 5 mm posterior interproximal pocket during PMT with a history of bleeding on probing (BOP). Group treatments were applied to the site at baseline and 6 months. Clinical attachment levels (CALs; primary outcome), probing depths (PDs), plaque, and BOP also were recorded at baseline and 6 and 12 months. In addition, gingival crevicular fluid was analyzed for an inflammation index ratio of interleukin (IL)-1b/IL-1 receptor antagonist (ra) using enzyme-linked immunosorbent assays. Results: All clinical parameters improved significantly (P <0.005) from baseline in both groups with no differences between groups at any time point. CAL decreased 17% (0.9 ± 0.8 mm) and 13% (0.7 ± 0.9 mm) in SRP + MM and 11% (0.7 ± 1.1 mm) and 21% (1.2 ± 0.9 mm) in SRP at 6 and 12 months, respectively. The odds of having BOP decreased 90% (down to 38% of patients) and 95% (26%) in SRP + MM and 82% (42%) and 82% (41%) in SRP at 6 and 12 months, respectively. IL-1β/IL-1ra decreased a significant 61% (P = 0.009) only in SRP + MM at 6 months. Conclusions: SRP of inflamed moderate pockets during 6- month PMT, with or without MMs, improves CALs, along with PDs and BOP over a 1-year period. The use of MMs did not result in an additional benefit over SRP alone.

Original languageEnglish (US)
Pages (from-to)1149-1157
Number of pages9
JournalJournal of periodontology
Volume87
Issue number10
DOIs
StatePublished - Oct 2016

Fingerprint

Root Planing
Minocycline
Microspheres
Randomized Controlled Trials
Maintenance
Inflammation
Hemorrhage
Periodontal Pocket
Interleukins
Gingival Crevicular Fluid
Therapeutics
Chronic Periodontitis
Interleukin-1 Receptors
Interleukin-1
Enzyme-Linked Immunosorbent Assay

Keywords

  • Inflammation
  • Interleukin-1
  • Interleukin-1 receptor antagonist protein
  • Minocycline
  • Periodontitis

ASJC Scopus subject areas

  • Periodontics

Cite this

Local minocycline effect on inflammation and clinical attachment during periodontal maintenance : Randomized clinical trial. / Killeen, Amy C; Harn, Jennifer A.; Erickson, Leah M.; Yu, Fang; Reinhardt, Richard A.

In: Journal of periodontology, Vol. 87, No. 10, 10.2016, p. 1149-1157.

Research output: Contribution to journalArticle

@article{fd14586745774279913f4ddc324f85cb,
title = "Local minocycline effect on inflammation and clinical attachment during periodontal maintenance: Randomized clinical trial",
abstract = "Background: Minocycline microspheres (MMs) are being used to treat residual inflamed periodontal pockets during periodontal maintenance therapy (PMT), but evidence for efficacy from randomized clinical trials is lacking. The purpose of this study is to evaluate the effect of MMs plus scaling and root planing (SRP) on these sites. Methods: Sixty patients with chronic periodontitis on 6- month PMT intervals to be followed for 1 year were randomized (51 completed the study) into two statistically similar groups, SRP + MM (aged 66.8 years) and SRP alone (aged 67 years), to treat a 5 mm posterior interproximal pocket during PMT with a history of bleeding on probing (BOP). Group treatments were applied to the site at baseline and 6 months. Clinical attachment levels (CALs; primary outcome), probing depths (PDs), plaque, and BOP also were recorded at baseline and 6 and 12 months. In addition, gingival crevicular fluid was analyzed for an inflammation index ratio of interleukin (IL)-1b/IL-1 receptor antagonist (ra) using enzyme-linked immunosorbent assays. Results: All clinical parameters improved significantly (P <0.005) from baseline in both groups with no differences between groups at any time point. CAL decreased 17{\%} (0.9 ± 0.8 mm) and 13{\%} (0.7 ± 0.9 mm) in SRP + MM and 11{\%} (0.7 ± 1.1 mm) and 21{\%} (1.2 ± 0.9 mm) in SRP at 6 and 12 months, respectively. The odds of having BOP decreased 90{\%} (down to 38{\%} of patients) and 95{\%} (26{\%}) in SRP + MM and 82{\%} (42{\%}) and 82{\%} (41{\%}) in SRP at 6 and 12 months, respectively. IL-1β/IL-1ra decreased a significant 61{\%} (P = 0.009) only in SRP + MM at 6 months. Conclusions: SRP of inflamed moderate pockets during 6- month PMT, with or without MMs, improves CALs, along with PDs and BOP over a 1-year period. The use of MMs did not result in an additional benefit over SRP alone.",
keywords = "Inflammation, Interleukin-1, Interleukin-1 receptor antagonist protein, Minocycline, Periodontitis",
author = "Killeen, {Amy C} and Harn, {Jennifer A.} and Erickson, {Leah M.} and Fang Yu and Reinhardt, {Richard A}",
year = "2016",
month = "10",
doi = "10.1902/jop.2016.150551",
language = "English (US)",
volume = "87",
pages = "1149--1157",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "10",

}

TY - JOUR

T1 - Local minocycline effect on inflammation and clinical attachment during periodontal maintenance

T2 - Randomized clinical trial

AU - Killeen, Amy C

AU - Harn, Jennifer A.

AU - Erickson, Leah M.

AU - Yu, Fang

AU - Reinhardt, Richard A

PY - 2016/10

Y1 - 2016/10

N2 - Background: Minocycline microspheres (MMs) are being used to treat residual inflamed periodontal pockets during periodontal maintenance therapy (PMT), but evidence for efficacy from randomized clinical trials is lacking. The purpose of this study is to evaluate the effect of MMs plus scaling and root planing (SRP) on these sites. Methods: Sixty patients with chronic periodontitis on 6- month PMT intervals to be followed for 1 year were randomized (51 completed the study) into two statistically similar groups, SRP + MM (aged 66.8 years) and SRP alone (aged 67 years), to treat a 5 mm posterior interproximal pocket during PMT with a history of bleeding on probing (BOP). Group treatments were applied to the site at baseline and 6 months. Clinical attachment levels (CALs; primary outcome), probing depths (PDs), plaque, and BOP also were recorded at baseline and 6 and 12 months. In addition, gingival crevicular fluid was analyzed for an inflammation index ratio of interleukin (IL)-1b/IL-1 receptor antagonist (ra) using enzyme-linked immunosorbent assays. Results: All clinical parameters improved significantly (P <0.005) from baseline in both groups with no differences between groups at any time point. CAL decreased 17% (0.9 ± 0.8 mm) and 13% (0.7 ± 0.9 mm) in SRP + MM and 11% (0.7 ± 1.1 mm) and 21% (1.2 ± 0.9 mm) in SRP at 6 and 12 months, respectively. The odds of having BOP decreased 90% (down to 38% of patients) and 95% (26%) in SRP + MM and 82% (42%) and 82% (41%) in SRP at 6 and 12 months, respectively. IL-1β/IL-1ra decreased a significant 61% (P = 0.009) only in SRP + MM at 6 months. Conclusions: SRP of inflamed moderate pockets during 6- month PMT, with or without MMs, improves CALs, along with PDs and BOP over a 1-year period. The use of MMs did not result in an additional benefit over SRP alone.

AB - Background: Minocycline microspheres (MMs) are being used to treat residual inflamed periodontal pockets during periodontal maintenance therapy (PMT), but evidence for efficacy from randomized clinical trials is lacking. The purpose of this study is to evaluate the effect of MMs plus scaling and root planing (SRP) on these sites. Methods: Sixty patients with chronic periodontitis on 6- month PMT intervals to be followed for 1 year were randomized (51 completed the study) into two statistically similar groups, SRP + MM (aged 66.8 years) and SRP alone (aged 67 years), to treat a 5 mm posterior interproximal pocket during PMT with a history of bleeding on probing (BOP). Group treatments were applied to the site at baseline and 6 months. Clinical attachment levels (CALs; primary outcome), probing depths (PDs), plaque, and BOP also were recorded at baseline and 6 and 12 months. In addition, gingival crevicular fluid was analyzed for an inflammation index ratio of interleukin (IL)-1b/IL-1 receptor antagonist (ra) using enzyme-linked immunosorbent assays. Results: All clinical parameters improved significantly (P <0.005) from baseline in both groups with no differences between groups at any time point. CAL decreased 17% (0.9 ± 0.8 mm) and 13% (0.7 ± 0.9 mm) in SRP + MM and 11% (0.7 ± 1.1 mm) and 21% (1.2 ± 0.9 mm) in SRP at 6 and 12 months, respectively. The odds of having BOP decreased 90% (down to 38% of patients) and 95% (26%) in SRP + MM and 82% (42%) and 82% (41%) in SRP at 6 and 12 months, respectively. IL-1β/IL-1ra decreased a significant 61% (P = 0.009) only in SRP + MM at 6 months. Conclusions: SRP of inflamed moderate pockets during 6- month PMT, with or without MMs, improves CALs, along with PDs and BOP over a 1-year period. The use of MMs did not result in an additional benefit over SRP alone.

KW - Inflammation

KW - Interleukin-1

KW - Interleukin-1 receptor antagonist protein

KW - Minocycline

KW - Periodontitis

UR - http://www.scopus.com/inward/record.url?scp=84989868780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989868780&partnerID=8YFLogxK

U2 - 10.1902/jop.2016.150551

DO - 10.1902/jop.2016.150551

M3 - Article

C2 - 27263325

AN - SCOPUS:84989868780

VL - 87

SP - 1149

EP - 1157

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 10

ER -