Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis

Michael K. Shaw, James B. Lorens, Archana Dhawan, Richard DalCanto, Harley Y. Tse, Alyssa B. Tran, Colleen Bonpane, Shanti L. Eswaran, Stefan Brocke, Nora Sarvetnick, Lawrence Steinman, Garry P. Nolan, C. Garrison Fathman

Research output: Contribution to journalArticle

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Abstract

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the central nervous system which serves as a model for the human disease multiple sclerosis. We demonstrate here that encephalitogenic T cells, transduced with a retroviral gene, construct to express interleukin 4, and can delay the onset and reduce the severity of EAE when adoptively transferred to myelin basic protein-immunized mice. Thus, T lymphocytes transduced with retrovital vectors can deliver 'regulatory cytokines' in a site-specific manner and may represent a viable therapeutic strategy for the treatment of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1711-1714
Number of pages4
JournalJournal of Experimental Medicine
Volume185
Issue number9
DOIs
Publication statusPublished - May 5 1997

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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