Local biochemical markers of bone turnover

Relationship to subsequent density of healing alveolar bone defects

Richard A Reinhardt, Van J. Sanderfer, Trudy A. Meinberg, Pirkka Nummikoski, Hsi Ming Lee, David B. Marx

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: This pilot study was designed to test whether biochemical markers of bone turnover in washes of periosteal or trabecular alveolar bone surfaces could be correlated with increases in bone density of an adjacent healing implant socket. Methods: Ten subjects had a canula inserted into the alveolar crest and sterile phosphate-buffered saline was washed over the periosteal and trabecular surfaces and collected. Surgical flaps were reflected, 5 mm diameter bone cores were removed from the bone wash site, and standardized radiographs were taken. The sites were allowed to heal for 12 weeks, and radiographs were repeated. Bone washes of the healing sites were also collected after 2 and 12 weeks. Washes were analysed for bone turnover markers osteocalcin (OC; radioimmunoassay) and C-terminal telopeptide of Type 1 collagen (ICTP; enzyme-linked immunosorbent assay (ELISA)), and blood component albumin (ALB; ELISA). Changes in bone density during healing were determined by radiographic absorptiometry. Results: OC/ALB and ICTP/ALB ratios were higher for trabecular than periosteal washes at baseline (p ≤ 0.01). Trabecular OC/ALB and ICTP/ALB were inversely correlated with increasing bone density of the healing bone core socket (r = -0.72, p = 0.03; Pearson's correlation coefficient). Conclusions: Biochemical markers of bone turnover in bone washes of specific alveolar bone sites may prove helpful in predicting how the bone density will increase around healing dental implants.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalJournal of Clinical Periodontology
Volume31
Issue number3
DOIs
StatePublished - Mar 1 2004

Fingerprint

Bone Remodeling
Biomarkers
Bone and Bones
Bone Density
Enzyme-Linked Immunosorbent Assay
Surgical Flaps
Dental Implants
Osteocalcin
Collagen Type I
Radioimmunoassay
Albumins
Phosphates

Keywords

  • Bone density
  • Bone turnover
  • Bone wash
  • ICTP
  • Osteocalcin
  • Radiographic absorptiometry

ASJC Scopus subject areas

  • Periodontics

Cite this

Local biochemical markers of bone turnover : Relationship to subsequent density of healing alveolar bone defects. / Reinhardt, Richard A; Sanderfer, Van J.; Meinberg, Trudy A.; Nummikoski, Pirkka; Lee, Hsi Ming; Marx, David B.

In: Journal of Clinical Periodontology, Vol. 31, No. 3, 01.03.2004, p. 223-228.

Research output: Contribution to journalArticle

Reinhardt, Richard A ; Sanderfer, Van J. ; Meinberg, Trudy A. ; Nummikoski, Pirkka ; Lee, Hsi Ming ; Marx, David B. / Local biochemical markers of bone turnover : Relationship to subsequent density of healing alveolar bone defects. In: Journal of Clinical Periodontology. 2004 ; Vol. 31, No. 3. pp. 223-228.
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