Liver transplantation for biliary atresia

Shunzaburo Iwatsuki, Byers W. Shaw, Thomas E. Starzl

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Orthotopic liver transplantation was performed 15 months to 20 years ago in 126 recipients, all of whom were under 18 years of age. Eighty-six of these pediatric recipients were treated before 1980 with azathioprine (or eyclophosphamide) and prednisone, to which antilymphocyte globulin (ALG) usually was added. One-year patient survival was 40%. In the last 40 cases, the new drug cyclosporine has been given with low doses of steroids. The one-year patient survival increased to 65%. Both in the pre-cyclosporine era and more recently, the survival of patients with biliary atresia has been lower than in the next largest category of patients, namely, those with liver-based inborn metabolic errors. The difficulty of operation in patients with biliary atresia has been greater than in recipients with other diagnoses, partly because of previous operations such as portoenterostomy (Kasai procedure). Hepatic portoenterostomy, worthwhile as it is, has posed technical difficulties for eventual liver transplantation, particularly when complicated Roux limb techniques or venting procedures have been applied. In our total experience the longest survival after liver replacement in a child whose original diagnosis was biliary atresia is 132/3 years.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalWorld Journal of Surgery
Volume8
Issue number1
DOIs
StatePublished - Feb 1 1984

Fingerprint

Biliary Atresia
Liver Transplantation
Survival
Cyclosporine
Hepatic Portoenterostomy
Antilymphocyte Serum
Liver
Azathioprine
Prednisone
Extremities
Steroids
Pediatrics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery

Cite this

Iwatsuki, S., Shaw, B. W., & Starzl, T. E. (1984). Liver transplantation for biliary atresia. World Journal of Surgery, 8(1), 51-56. https://doi.org/10.1007/BF01658363

Liver transplantation for biliary atresia. / Iwatsuki, Shunzaburo; Shaw, Byers W.; Starzl, Thomas E.

In: World Journal of Surgery, Vol. 8, No. 1, 01.02.1984, p. 51-56.

Research output: Contribution to journalArticle

Iwatsuki, S, Shaw, BW & Starzl, TE 1984, 'Liver transplantation for biliary atresia', World Journal of Surgery, vol. 8, no. 1, pp. 51-56. https://doi.org/10.1007/BF01658363
Iwatsuki, Shunzaburo ; Shaw, Byers W. ; Starzl, Thomas E. / Liver transplantation for biliary atresia. In: World Journal of Surgery. 1984 ; Vol. 8, No. 1. pp. 51-56.
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