Cyclopropenoid fatty acids in the diet of rainbow trout caused significant reductions in liver protein and activity of glucose 6 phosphate dehydrogenase, NADP linked isocitrate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase. Changes in total activity were usually accompanied by similar changes in specific activity. The activity of glucose 6 phosphate dehydrogenase appeared to be more sensitive to the ingestion of cyclopropenoid fatty acids than the other dehydrogenases studied. Feeding 20 ppb aflatoxin B1 to rainbow trout did not significantly change the activity of the dehydrogenases except for a small increase in the activity of glucose 6 phosphate dehydrogenase after 21 days of feeding. Relationships of these changes to the cocarcinogenicity of cyclopropenoid fatty acids and the carcinogenicity of aflatoxin are discussed.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Lipid Research|
|Publication status||Published - Dec 1 1973|
ASJC Scopus subject areas
- Cell Biology