Liver Cancer in Transgenic Mice Carrying the Human Immunodeficiency Virus tat Gene

Jonathan Vogel, Steven Heye Hinrichs, Laura A. Napolitano, Lien Ngo, Gilbert Jay

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Patients with the acquired immunodeficiency syndrome are at risk to develop a variety of different cancers. Based on epidemiolã³gica! data, Kaposi's sarcoma and non-Hodgkin's lymphoma have been clearly asso ciated with infection by the human immunodeficiency virus (HIV). Ad ditional cancers such as basal cell and squamous cell carcinomas, mela noma, and hepatocellular carcinoma have also been reported to be asso ciated with a diagnosis of acquired immunodeficiency syndrome. A direct causal role of HIV has yet to be established for any of these cancers. We now report that transgenic mice carrying the HIV tat gene develop a high incidence of hepatocellular carcinoma after a long latency and that these changes in the liver are likely to be initiated by extrahepatic growth signals from the tat expressing cells in these mice. We predict that as acquired immunodeficiency syndrome patients begin to respond to ther apy and show prolonged survival, such “secondary” malignancies induced by HIV will become increasingly prevalent.

Original languageEnglish (US)
Pages (from-to)6686-6690
Number of pages5
JournalCancer Research
Volume51
Issue number24
StatePublished - Jan 1 1991

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tat Genes
Liver Neoplasms
Transgenic Mice
HIV
Acquired Immunodeficiency Syndrome
Hepatocellular Carcinoma
Neoplasms
Noma
Kaposi's Sarcoma
Non-Hodgkin's Lymphoma
Squamous Cell Carcinoma
Survival
Liver
Incidence
Growth
Infection

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Vogel, J., Hinrichs, S. H., Napolitano, L. A., Ngo, L., & Jay, G. (1991). Liver Cancer in Transgenic Mice Carrying the Human Immunodeficiency Virus tat Gene. Cancer Research, 51(24), 6686-6690.

Liver Cancer in Transgenic Mice Carrying the Human Immunodeficiency Virus tat Gene. / Vogel, Jonathan; Hinrichs, Steven Heye; Napolitano, Laura A.; Ngo, Lien; Jay, Gilbert.

In: Cancer Research, Vol. 51, No. 24, 01.01.1991, p. 6686-6690.

Research output: Contribution to journalArticle

Vogel, J, Hinrichs, SH, Napolitano, LA, Ngo, L & Jay, G 1991, 'Liver Cancer in Transgenic Mice Carrying the Human Immunodeficiency Virus tat Gene', Cancer Research, vol. 51, no. 24, pp. 6686-6690.
Vogel, Jonathan ; Hinrichs, Steven Heye ; Napolitano, Laura A. ; Ngo, Lien ; Jay, Gilbert. / Liver Cancer in Transgenic Mice Carrying the Human Immunodeficiency Virus tat Gene. In: Cancer Research. 1991 ; Vol. 51, No. 24. pp. 6686-6690.
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