Liver and kidney transplantation in children receiving cyclosporin A and steroids

Thomas E. Starzl, Shunzaburo Iwatsuki, J. Jeffrey Malatack, Basil J. Zitelli, J. Carlton Gartner, Thomas R. Hakala, J. Thomas Rosenthal, Byers W. Shaw

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The new immunosuppressive agent, cyclosporin A, was used with low doses of steroids to treat eight patients undergoing hepatic transplantation and three patients undergoing cadaveric renal transplantation. Seven of the eight liver recipients are well, including one who was given two livers. The three kidney recipients, who had developed cytotoxic antibodies after previously rejecting grafts with conventional immunosuppressive therapy, have had good results despite conditions which usually preclude attempts at transplantation. The ability to control rejection effectively and safely without chronic high-dose steroid therapy may make the described therapeutic regimen valuable for pediatric recipients of whole organs.

Original languageEnglish (US)
Pages (from-to)681-686
Number of pages6
JournalThe Journal of Pediatrics
Volume100
Issue number5
DOIs
StatePublished - May 1982

Fingerprint

Liver Transplantation
Kidney Transplantation
Cyclosporine
Steroids
Immunosuppressive Agents
Liver
Therapeutics
Transplantation
Pediatrics
Transplants
Kidney
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Starzl, T. E., Iwatsuki, S., Malatack, J. J., Zitelli, B. J., Gartner, J. C., Hakala, T. R., ... Shaw, B. W. (1982). Liver and kidney transplantation in children receiving cyclosporin A and steroids. The Journal of Pediatrics, 100(5), 681-686. https://doi.org/10.1016/S0022-3476(82)80564-7

Liver and kidney transplantation in children receiving cyclosporin A and steroids. / Starzl, Thomas E.; Iwatsuki, Shunzaburo; Malatack, J. Jeffrey; Zitelli, Basil J.; Gartner, J. Carlton; Hakala, Thomas R.; Rosenthal, J. Thomas; Shaw, Byers W.

In: The Journal of Pediatrics, Vol. 100, No. 5, 05.1982, p. 681-686.

Research output: Contribution to journalArticle

Starzl, TE, Iwatsuki, S, Malatack, JJ, Zitelli, BJ, Gartner, JC, Hakala, TR, Rosenthal, JT & Shaw, BW 1982, 'Liver and kidney transplantation in children receiving cyclosporin A and steroids', The Journal of Pediatrics, vol. 100, no. 5, pp. 681-686. https://doi.org/10.1016/S0022-3476(82)80564-7
Starzl TE, Iwatsuki S, Malatack JJ, Zitelli BJ, Gartner JC, Hakala TR et al. Liver and kidney transplantation in children receiving cyclosporin A and steroids. The Journal of Pediatrics. 1982 May;100(5):681-686. https://doi.org/10.1016/S0022-3476(82)80564-7
Starzl, Thomas E. ; Iwatsuki, Shunzaburo ; Malatack, J. Jeffrey ; Zitelli, Basil J. ; Gartner, J. Carlton ; Hakala, Thomas R. ; Rosenthal, J. Thomas ; Shaw, Byers W. / Liver and kidney transplantation in children receiving cyclosporin A and steroids. In: The Journal of Pediatrics. 1982 ; Vol. 100, No. 5. pp. 681-686.
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