Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry

Qingsheng Li, Ming Zeng, Lijie Duan, James E. Voss, Anthony J. Smith, Stefan Pambuccian, Liang Shang, Stephen Wietgrefe, Peter J. Southern, Cavan S. Reilly, Pamela J. Skinner, Mary L. Zupancic, John V. Carlis, Michael Piatak, Diane Waterman, R. Keith Reeves, Katherine Masek-Hammerman, Cynthia A. Derdeyn, Michael D. Alpert, David T. EvansHeinz Kohler, Sybille Müller, James Robinson, Jeffrey D. Lifson, Dennis R. Burton, R. Paul Johnson, Ashley T. Haase

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG Abs reactive with viral envelope glycoprotein gp41 trimers, and these Abs are concentrated on the path of virus entry by the neonatal FcR in cervical reserve epithelium and in vaginal epithelium. This local Ab production and delivery system correlated spatially and temporally with the maturation of local protection against high-dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of Abs at mucosal frontlines could aid in the development of an effective vaccine to protect women against HIV-1.

Original languageEnglish (US)
Pages (from-to)3113-3125
Number of pages13
JournalJournal of Immunology
Volume193
Issue number6
DOIs
StatePublished - Sep 15 2014

Fingerprint

Simian Immunodeficiency Virus
Virus Internalization
Antibody Formation
Vaccines
Epithelium
Plasma Cells
Macaca mulatta
SAIDS Vaccines
Attenuated Vaccines
HIV-1
Glycoproteins
Vaccination
Animal Models
Immunoglobulin G
HIV
Tertiary Lymphoid Structures

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Live simian immunodeficiency virus vaccine correlate of protection : Local antibody production and concentration on the path of virus entry. / Li, Qingsheng; Zeng, Ming; Duan, Lijie; Voss, James E.; Smith, Anthony J.; Pambuccian, Stefan; Shang, Liang; Wietgrefe, Stephen; Southern, Peter J.; Reilly, Cavan S.; Skinner, Pamela J.; Zupancic, Mary L.; Carlis, John V.; Piatak, Michael; Waterman, Diane; Reeves, R. Keith; Masek-Hammerman, Katherine; Derdeyn, Cynthia A.; Alpert, Michael D.; Evans, David T.; Kohler, Heinz; Müller, Sybille; Robinson, James; Lifson, Jeffrey D.; Burton, Dennis R.; Johnson, R. Paul; Haase, Ashley T.

In: Journal of Immunology, Vol. 193, No. 6, 15.09.2014, p. 3113-3125.

Research output: Contribution to journalArticle

Li, Q, Zeng, M, Duan, L, Voss, JE, Smith, AJ, Pambuccian, S, Shang, L, Wietgrefe, S, Southern, PJ, Reilly, CS, Skinner, PJ, Zupancic, ML, Carlis, JV, Piatak, M, Waterman, D, Reeves, RK, Masek-Hammerman, K, Derdeyn, CA, Alpert, MD, Evans, DT, Kohler, H, Müller, S, Robinson, J, Lifson, JD, Burton, DR, Johnson, RP & Haase, AT 2014, 'Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry', Journal of Immunology, vol. 193, no. 6, pp. 3113-3125. https://doi.org/10.4049/jimmunol.1400820
Li, Qingsheng ; Zeng, Ming ; Duan, Lijie ; Voss, James E. ; Smith, Anthony J. ; Pambuccian, Stefan ; Shang, Liang ; Wietgrefe, Stephen ; Southern, Peter J. ; Reilly, Cavan S. ; Skinner, Pamela J. ; Zupancic, Mary L. ; Carlis, John V. ; Piatak, Michael ; Waterman, Diane ; Reeves, R. Keith ; Masek-Hammerman, Katherine ; Derdeyn, Cynthia A. ; Alpert, Michael D. ; Evans, David T. ; Kohler, Heinz ; Müller, Sybille ; Robinson, James ; Lifson, Jeffrey D. ; Burton, Dennis R. ; Johnson, R. Paul ; Haase, Ashley T. / Live simian immunodeficiency virus vaccine correlate of protection : Local antibody production and concentration on the path of virus entry. In: Journal of Immunology. 2014 ; Vol. 193, No. 6. pp. 3113-3125.
@article{9f45fc53e9ba493dbae52efbd1d0587e,
title = "Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry",
abstract = "We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG Abs reactive with viral envelope glycoprotein gp41 trimers, and these Abs are concentrated on the path of virus entry by the neonatal FcR in cervical reserve epithelium and in vaginal epithelium. This local Ab production and delivery system correlated spatially and temporally with the maturation of local protection against high-dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of Abs at mucosal frontlines could aid in the development of an effective vaccine to protect women against HIV-1.",
author = "Qingsheng Li and Ming Zeng and Lijie Duan and Voss, {James E.} and Smith, {Anthony J.} and Stefan Pambuccian and Liang Shang and Stephen Wietgrefe and Southern, {Peter J.} and Reilly, {Cavan S.} and Skinner, {Pamela J.} and Zupancic, {Mary L.} and Carlis, {John V.} and Michael Piatak and Diane Waterman and Reeves, {R. Keith} and Katherine Masek-Hammerman and Derdeyn, {Cynthia A.} and Alpert, {Michael D.} and Evans, {David T.} and Heinz Kohler and Sybille M{\"u}ller and James Robinson and Lifson, {Jeffrey D.} and Burton, {Dennis R.} and Johnson, {R. Paul} and Haase, {Ashley T.}",
year = "2014",
month = "9",
day = "15",
doi = "10.4049/jimmunol.1400820",
language = "English (US)",
volume = "193",
pages = "3113--3125",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "6",

}

TY - JOUR

T1 - Live simian immunodeficiency virus vaccine correlate of protection

T2 - Local antibody production and concentration on the path of virus entry

AU - Li, Qingsheng

AU - Zeng, Ming

AU - Duan, Lijie

AU - Voss, James E.

AU - Smith, Anthony J.

AU - Pambuccian, Stefan

AU - Shang, Liang

AU - Wietgrefe, Stephen

AU - Southern, Peter J.

AU - Reilly, Cavan S.

AU - Skinner, Pamela J.

AU - Zupancic, Mary L.

AU - Carlis, John V.

AU - Piatak, Michael

AU - Waterman, Diane

AU - Reeves, R. Keith

AU - Masek-Hammerman, Katherine

AU - Derdeyn, Cynthia A.

AU - Alpert, Michael D.

AU - Evans, David T.

AU - Kohler, Heinz

AU - Müller, Sybille

AU - Robinson, James

AU - Lifson, Jeffrey D.

AU - Burton, Dennis R.

AU - Johnson, R. Paul

AU - Haase, Ashley T.

PY - 2014/9/15

Y1 - 2014/9/15

N2 - We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG Abs reactive with viral envelope glycoprotein gp41 trimers, and these Abs are concentrated on the path of virus entry by the neonatal FcR in cervical reserve epithelium and in vaginal epithelium. This local Ab production and delivery system correlated spatially and temporally with the maturation of local protection against high-dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of Abs at mucosal frontlines could aid in the development of an effective vaccine to protect women against HIV-1.

AB - We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in the rhesus macaque female reproductive tract. The plasma cells and ectopic follicles produce IgG Abs reactive with viral envelope glycoprotein gp41 trimers, and these Abs are concentrated on the path of virus entry by the neonatal FcR in cervical reserve epithelium and in vaginal epithelium. This local Ab production and delivery system correlated spatially and temporally with the maturation of local protection against high-dose pathogenic SIV vaginal challenge. Thus, designing vaccines to elicit production and concentration of Abs at mucosal frontlines could aid in the development of an effective vaccine to protect women against HIV-1.

UR - http://www.scopus.com/inward/record.url?scp=84926498205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926498205&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.1400820

DO - 10.4049/jimmunol.1400820

M3 - Article

C2 - 25135832

AN - SCOPUS:84926498205

VL - 193

SP - 3113

EP - 3125

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 6

ER -