Lithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatology

Jacob Kerbeshian, Larry Burd, Wayne Fisher

Research output: Contribution to journalArticle

58 Scopus citations


Two patients with infantile autism by DSM-III criteria and with atypical bipolar symptomatology were treated with lithium carbonate. Both children demonstrated a significant response with levels above 1.0mEq/liter. Factors that may be useful in discovering patients with autism who may respond to lithium treatment include a family history of bipolar illness; extreme hyperactivity not responsive to a stimulant; a definite cyclic component to symptomatic behaviors; sustained laughter, irritability, or giddiness that is not stereotypic; and/or the presence of many or all of the symptom criteria for bipolar disorder.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalJournal of Clinical Psychopharmacology
Issue number6
Publication statusPublished - Dec 1987


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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