Lipids increase after solitary pancreas transplantation

Susan A. Henley, Jaweed Akhter, Robert J. Stratta, Lynn R Mack, Suzanne J. Miller, Kecia Frisbie, Rodney Taylor, Judi M. Erickson, John P. Leone, Elizabeth Lyden, Tanaporn Ratanasuwan, Jennifer Lynn Larsen

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - The aims of this study were to determine 1) changes in lipids after solitary pancreas transplantation (SPTX) in patients with type I diabetes and 2) factors that influence those changes. RESEARCH DESIGN AND METHODS - Lipids were evaluated prospectively in 24 patients who underwent SPTX. Three were excluded because of early graft failure. The remaining patients (n = 21; 13 men, 8 women) were studied for changes in lipids over time (pre-SPTX, 0-2, 3-6, 7-12, and >12 months). Glycohemoglobin, serum creatinine, BMI, and medications were also analyzed for their effects on lipid changes. RESULTS - Cholesterol, HDL, and LDL decreased in the immediate postoperative period (0-2 months), whereas triglycerides (TGs) increased (P < 0.05). At 3-6 months, cholesterol, HDL, and TG were higher than before the SPTX, whereas LDL returned to pre-SPTX levels. After 12 months, HDL and TG remained higher than their pre-SPTX levels (P < 0.05). During the study, systolic and diastolic blood pressure increased, renal function decreased, glycohemoglobin improved, and weight was unchanged. Changes in cholesterol/HDL ratio, HDL, and TG correlated with changes in prednisone dose (P < 0.05), and changes in TG correlated with changes in creatinine (P < 0.05). The same pattern of lipids occurred in patients prescribed or not prescribed hypolipidemic agents. CONCLUSIONS - Lipids do not improve within the 1st year after SPTX, despite improved glycemic control and blood pressure control, and renal function is worse. These results are in contrast to those reported for combined kidney-pancreas transplantation, where lipids, blood pressure, and renal function improved immediately after transplant. Further studies are needed to determine whether lipids continue to change with time after SPTX. The impact of these changes after SPTX on overall cardiovascular risk is unknown.

Original languageEnglish (US)
Pages (from-to)320-327
Number of pages8
JournalDiabetes Care
Volume22
Issue number2
DOIs
StatePublished - Feb 1 1999

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Pancreas Transplantation
Lipids
Triglycerides
HDL Cholesterol
Blood Pressure
Kidney
Creatinine
Transplants
Hypolipidemic Agents
Prednisone
Type 1 Diabetes Mellitus
Postoperative Period
Kidney Transplantation
Type 2 Diabetes Mellitus
Research Design
Weights and Measures

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Henley, S. A., Akhter, J., Stratta, R. J., Mack, L. R., Miller, S. J., Frisbie, K., ... Larsen, J. L. (1999). Lipids increase after solitary pancreas transplantation. Diabetes Care, 22(2), 320-327. https://doi.org/10.2337/diacare.22.2.320

Lipids increase after solitary pancreas transplantation. / Henley, Susan A.; Akhter, Jaweed; Stratta, Robert J.; Mack, Lynn R; Miller, Suzanne J.; Frisbie, Kecia; Taylor, Rodney; Erickson, Judi M.; Leone, John P.; Lyden, Elizabeth; Ratanasuwan, Tanaporn; Larsen, Jennifer Lynn.

In: Diabetes Care, Vol. 22, No. 2, 01.02.1999, p. 320-327.

Research output: Contribution to journalArticle

Henley, SA, Akhter, J, Stratta, RJ, Mack, LR, Miller, SJ, Frisbie, K, Taylor, R, Erickson, JM, Leone, JP, Lyden, E, Ratanasuwan, T & Larsen, JL 1999, 'Lipids increase after solitary pancreas transplantation', Diabetes Care, vol. 22, no. 2, pp. 320-327. https://doi.org/10.2337/diacare.22.2.320
Henley SA, Akhter J, Stratta RJ, Mack LR, Miller SJ, Frisbie K et al. Lipids increase after solitary pancreas transplantation. Diabetes Care. 1999 Feb 1;22(2):320-327. https://doi.org/10.2337/diacare.22.2.320
Henley, Susan A. ; Akhter, Jaweed ; Stratta, Robert J. ; Mack, Lynn R ; Miller, Suzanne J. ; Frisbie, Kecia ; Taylor, Rodney ; Erickson, Judi M. ; Leone, John P. ; Lyden, Elizabeth ; Ratanasuwan, Tanaporn ; Larsen, Jennifer Lynn. / Lipids increase after solitary pancreas transplantation. In: Diabetes Care. 1999 ; Vol. 22, No. 2. pp. 320-327.
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abstract = "OBJECTIVE - The aims of this study were to determine 1) changes in lipids after solitary pancreas transplantation (SPTX) in patients with type I diabetes and 2) factors that influence those changes. RESEARCH DESIGN AND METHODS - Lipids were evaluated prospectively in 24 patients who underwent SPTX. Three were excluded because of early graft failure. The remaining patients (n = 21; 13 men, 8 women) were studied for changes in lipids over time (pre-SPTX, 0-2, 3-6, 7-12, and >12 months). Glycohemoglobin, serum creatinine, BMI, and medications were also analyzed for their effects on lipid changes. RESULTS - Cholesterol, HDL, and LDL decreased in the immediate postoperative period (0-2 months), whereas triglycerides (TGs) increased (P < 0.05). At 3-6 months, cholesterol, HDL, and TG were higher than before the SPTX, whereas LDL returned to pre-SPTX levels. After 12 months, HDL and TG remained higher than their pre-SPTX levels (P < 0.05). During the study, systolic and diastolic blood pressure increased, renal function decreased, glycohemoglobin improved, and weight was unchanged. Changes in cholesterol/HDL ratio, HDL, and TG correlated with changes in prednisone dose (P < 0.05), and changes in TG correlated with changes in creatinine (P < 0.05). The same pattern of lipids occurred in patients prescribed or not prescribed hypolipidemic agents. CONCLUSIONS - Lipids do not improve within the 1st year after SPTX, despite improved glycemic control and blood pressure control, and renal function is worse. These results are in contrast to those reported for combined kidney-pancreas transplantation, where lipids, blood pressure, and renal function improved immediately after transplant. Further studies are needed to determine whether lipids continue to change with time after SPTX. The impact of these changes after SPTX on overall cardiovascular risk is unknown.",
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AU - Frisbie, Kecia

AU - Taylor, Rodney

AU - Erickson, Judi M.

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AU - Ratanasuwan, Tanaporn

AU - Larsen, Jennifer Lynn

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N2 - OBJECTIVE - The aims of this study were to determine 1) changes in lipids after solitary pancreas transplantation (SPTX) in patients with type I diabetes and 2) factors that influence those changes. RESEARCH DESIGN AND METHODS - Lipids were evaluated prospectively in 24 patients who underwent SPTX. Three were excluded because of early graft failure. The remaining patients (n = 21; 13 men, 8 women) were studied for changes in lipids over time (pre-SPTX, 0-2, 3-6, 7-12, and >12 months). Glycohemoglobin, serum creatinine, BMI, and medications were also analyzed for their effects on lipid changes. RESULTS - Cholesterol, HDL, and LDL decreased in the immediate postoperative period (0-2 months), whereas triglycerides (TGs) increased (P < 0.05). At 3-6 months, cholesterol, HDL, and TG were higher than before the SPTX, whereas LDL returned to pre-SPTX levels. After 12 months, HDL and TG remained higher than their pre-SPTX levels (P < 0.05). During the study, systolic and diastolic blood pressure increased, renal function decreased, glycohemoglobin improved, and weight was unchanged. Changes in cholesterol/HDL ratio, HDL, and TG correlated with changes in prednisone dose (P < 0.05), and changes in TG correlated with changes in creatinine (P < 0.05). The same pattern of lipids occurred in patients prescribed or not prescribed hypolipidemic agents. CONCLUSIONS - Lipids do not improve within the 1st year after SPTX, despite improved glycemic control and blood pressure control, and renal function is worse. These results are in contrast to those reported for combined kidney-pancreas transplantation, where lipids, blood pressure, and renal function improved immediately after transplant. Further studies are needed to determine whether lipids continue to change with time after SPTX. The impact of these changes after SPTX on overall cardiovascular risk is unknown.

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