Lipid status after pancreas-kidney transplantation

Jennifer Lynn Larsen, Robert J. Stratta, Claire F. Ozaki, Rodney J. Taylor, Suzanne A. Miller, W. C. Duckworth

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - This study was performed to determine the net effects of euglycemia, resolution of renal failure, immunosuppressant drugs, and hyperinsulinemia on fasting lipid profiles of patients with renal failure and insulin-dependent diabetes mellitus (IDDM) after combined pancreas-kidney transplantation (PKT). RESEARCH DESIGN AND METHODS - Thirty subjects with IDDM received PKT between April 1989 and October 1990, and all were studied. Mean ± SE age was 35.2 ± 1.3 yr; 19 recipients were men, and 11 were women. All had a functioning pancreatic allograft post-PKT. Fasting lipid profiles including total cholesterol (C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-chol), and C/HDL-chol were compared before and after PKT (38-555 days divided into groups: preoperation and 0-2, 3-8, and 9-19 mo). RESULTS - Significant hyperlipidemia was observed preoperatively (means ± SE): C, 5.92 ± 0.27 mM; HDL-chol, 1.07 ± 0.09 mM; TG, 5.85 ± 0.56 mM; and C/HDL-chol, 6.49 ± 0.83 All lipids and C/HDL-chol dropped immediately after PKT (0-2 mo vs. preoperation, all P < 0.01, except HDL-chol). After this immediate postoperative period, C, HDL-chol, and TG stabilized at new concentrations. C (5.44 ± 0.22 mM) and TG (4.54 ± 0.48 mM) levels were less than preoperation (not statistically significant and P < 0.05, respectively). HDL-chol was greater than preoperative values (1.29 ± 0.06 mM, P < 0.05). C/HDL-chol dropped after PKT (0-2 mo, 4.85 ± 0.18, P < 0.01) and continued to decrease throughout the observation period (3-8 mo, 4.42 ± 0.23; 9-19 mo, 4.23 ± 0.23; both P < 0.01 vs. preoperation). There was no statistical difference between lipid concentrations in male and female subjects. CONCLUSIONS - The lipid status of subjects with IDDM and renal failure was abnormal before PKT and once lipid concentrations stabilized after PKT (>2 mo), HDL-chol was higher and TG and C/HDL-chol levels were significantly lower than preoperative values. If these changes are sustained, risk of future cardiovascular disease in this group of patients might be significantly reduced.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalDiabetes Care
Volume15
Issue number1
DOIs
StatePublished - Jan 1 1992

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Pancreas Transplantation
Kidney Transplantation
HDL Cholesterol
Lipids
Triglycerides
Type 1 Diabetes Mellitus
Renal Insufficiency
Fasting
Hyperinsulinism
Immunosuppressive Agents
Hyperlipidemias
Allografts
Research Design
Cardiovascular Diseases
Cholesterol
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Larsen, J. L., Stratta, R. J., Ozaki, C. F., Taylor, R. J., Miller, S. A., & Duckworth, W. C. (1992). Lipid status after pancreas-kidney transplantation. Diabetes Care, 15(1), 35-42. https://doi.org/10.2337/diacare.15.1.35

Lipid status after pancreas-kidney transplantation. / Larsen, Jennifer Lynn; Stratta, Robert J.; Ozaki, Claire F.; Taylor, Rodney J.; Miller, Suzanne A.; Duckworth, W. C.

In: Diabetes Care, Vol. 15, No. 1, 01.01.1992, p. 35-42.

Research output: Contribution to journalArticle

Larsen, JL, Stratta, RJ, Ozaki, CF, Taylor, RJ, Miller, SA & Duckworth, WC 1992, 'Lipid status after pancreas-kidney transplantation', Diabetes Care, vol. 15, no. 1, pp. 35-42. https://doi.org/10.2337/diacare.15.1.35
Larsen JL, Stratta RJ, Ozaki CF, Taylor RJ, Miller SA, Duckworth WC. Lipid status after pancreas-kidney transplantation. Diabetes Care. 1992 Jan 1;15(1):35-42. https://doi.org/10.2337/diacare.15.1.35
Larsen, Jennifer Lynn ; Stratta, Robert J. ; Ozaki, Claire F. ; Taylor, Rodney J. ; Miller, Suzanne A. ; Duckworth, W. C. / Lipid status after pancreas-kidney transplantation. In: Diabetes Care. 1992 ; Vol. 15, No. 1. pp. 35-42.
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AU - Stratta, Robert J.

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AU - Duckworth, W. C.

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N2 - OBJECTIVE - This study was performed to determine the net effects of euglycemia, resolution of renal failure, immunosuppressant drugs, and hyperinsulinemia on fasting lipid profiles of patients with renal failure and insulin-dependent diabetes mellitus (IDDM) after combined pancreas-kidney transplantation (PKT). RESEARCH DESIGN AND METHODS - Thirty subjects with IDDM received PKT between April 1989 and October 1990, and all were studied. Mean ± SE age was 35.2 ± 1.3 yr; 19 recipients were men, and 11 were women. All had a functioning pancreatic allograft post-PKT. Fasting lipid profiles including total cholesterol (C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-chol), and C/HDL-chol were compared before and after PKT (38-555 days divided into groups: preoperation and 0-2, 3-8, and 9-19 mo). RESULTS - Significant hyperlipidemia was observed preoperatively (means ± SE): C, 5.92 ± 0.27 mM; HDL-chol, 1.07 ± 0.09 mM; TG, 5.85 ± 0.56 mM; and C/HDL-chol, 6.49 ± 0.83 All lipids and C/HDL-chol dropped immediately after PKT (0-2 mo vs. preoperation, all P < 0.01, except HDL-chol). After this immediate postoperative period, C, HDL-chol, and TG stabilized at new concentrations. C (5.44 ± 0.22 mM) and TG (4.54 ± 0.48 mM) levels were less than preoperation (not statistically significant and P < 0.05, respectively). HDL-chol was greater than preoperative values (1.29 ± 0.06 mM, P < 0.05). C/HDL-chol dropped after PKT (0-2 mo, 4.85 ± 0.18, P < 0.01) and continued to decrease throughout the observation period (3-8 mo, 4.42 ± 0.23; 9-19 mo, 4.23 ± 0.23; both P < 0.01 vs. preoperation). There was no statistical difference between lipid concentrations in male and female subjects. CONCLUSIONS - The lipid status of subjects with IDDM and renal failure was abnormal before PKT and once lipid concentrations stabilized after PKT (>2 mo), HDL-chol was higher and TG and C/HDL-chol levels were significantly lower than preoperative values. If these changes are sustained, risk of future cardiovascular disease in this group of patients might be significantly reduced.

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