Linkage investigations of dominantly inherited diseases in man

William J Kimberling, R. A. Taylor, H. A. Lubs

Research output: Contribution to journalArticle

Abstract

Several large families with dominantly inherited diseases were studied. The purpose of the investigation was to determine the linkage relationships between these diseases and several other genetic markers. The disorders included in the study were spherocytosis, dominant congenital cataract, polycystic kidney disease, corneal lattice dystrophy, neurofibromatosis, Waardenberg's syndrome and Huntington's chorea. Significant linkages were found for spherocytosis and congenital cataract. Spherocytosis was found to be linked to Gm at theta=0.27. The recombination fraction was not determined between sexes. Congenital cataract was also found to be linked to Gm. When the authors' scores were added to those kindly supplied by Dr. Renwick, the linkage was significant at theta=0.07.

Original languageEnglish (US)
JournalUnknown Journal
VolumeNo.397
StatePublished - Jan 1 1976

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Cataract
Polycystic Kidney Diseases
Neurofibromatoses
Huntington Disease
Genetic Markers
Genetic Recombination
Type 1 Spherocytosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kimberling, W. J., Taylor, R. A., & Lubs, H. A. (1976). Linkage investigations of dominantly inherited diseases in man. Unknown Journal, No.397.

Linkage investigations of dominantly inherited diseases in man. / Kimberling, William J; Taylor, R. A.; Lubs, H. A.

In: Unknown Journal, Vol. No.397, 01.01.1976.

Research output: Contribution to journalArticle

Kimberling, WJ, Taylor, RA & Lubs, HA 1976, 'Linkage investigations of dominantly inherited diseases in man', Unknown Journal, vol. No.397.
Kimberling WJ, Taylor RA, Lubs HA. Linkage investigations of dominantly inherited diseases in man. Unknown Journal. 1976 Jan 1;No.397.
Kimberling, William J ; Taylor, R. A. ; Lubs, H. A. / Linkage investigations of dominantly inherited diseases in man. In: Unknown Journal. 1976 ; Vol. No.397.
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