Linkage analysis of attention deficit hyperactivity disorder

Stephen V. Faraone, Alysa E. Doyle, Jessica Lasky-Su, Pamela B. Sklar, Eugene D'Angelo, Joseph Gonzalez-Heydrich, Christopher J Kratochvil, Eric Mick, Kristy Klein, Amy J. Rezac, Joseph Biederman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Results of behavioral genetic and molecular genetic studies have converged to suggest that both genes contribute to the development of ADHD. Although prior linkage studies have produced intriguing results, their results have been inconsistent, with no clear pattern of results emerging across studies. We genotyped 5,980 SNPs across the genome in 1,187 individuals from families with children diagnosed with ADHD. We then performed two nonparametric linkage analyses on ADHD families: (1) an affected sibling pair linkage analysis on 217 families with 601 siblings diagnosed with ADHD and (2) a variance components linkage analysis using the number of ADHD symptoms as the phenotype on 260 families with 1,100 phenotyped siblings. The affection status linkage analysis had a maximum LOD score of 1.85 on chromosome 8 at 54.2 cM. The maximum LOD score in the variance components linkage analysis was 0.8 on chromosome 8 at 93.4 cM. The absence of regions of significant or suggestive linkage in these data suggest that there are no genes of large effect contributing to the ADHD phenotype.

Original languageEnglish (US)
Pages (from-to)1387-1391
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number8
DOIs
StatePublished - Dec 5 2008

Fingerprint

Attention Deficit Disorder with Hyperactivity
Siblings
Chromosomes, Human, Pair 8
Behavioral Genetics
Phenotype
Information Storage and Retrieval
Genes
Single Nucleotide Polymorphism
Molecular Biology
Genome

Keywords

  • ADHD
  • Linkage analysis
  • SNPs

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Faraone, S. V., Doyle, A. E., Lasky-Su, J., Sklar, P. B., D'Angelo, E., Gonzalez-Heydrich, J., ... Biederman, J. (2008). Linkage analysis of attention deficit hyperactivity disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 147(8), 1387-1391. https://doi.org/10.1002/ajmg.b.30631

Linkage analysis of attention deficit hyperactivity disorder. / Faraone, Stephen V.; Doyle, Alysa E.; Lasky-Su, Jessica; Sklar, Pamela B.; D'Angelo, Eugene; Gonzalez-Heydrich, Joseph; Kratochvil, Christopher J; Mick, Eric; Klein, Kristy; Rezac, Amy J.; Biederman, Joseph.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 147, No. 8, 05.12.2008, p. 1387-1391.

Research output: Contribution to journalArticle

Faraone, SV, Doyle, AE, Lasky-Su, J, Sklar, PB, D'Angelo, E, Gonzalez-Heydrich, J, Kratochvil, CJ, Mick, E, Klein, K, Rezac, AJ & Biederman, J 2008, 'Linkage analysis of attention deficit hyperactivity disorder', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 147, no. 8, pp. 1387-1391. https://doi.org/10.1002/ajmg.b.30631
Faraone SV, Doyle AE, Lasky-Su J, Sklar PB, D'Angelo E, Gonzalez-Heydrich J et al. Linkage analysis of attention deficit hyperactivity disorder. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2008 Dec 5;147(8):1387-1391. https://doi.org/10.1002/ajmg.b.30631
Faraone, Stephen V. ; Doyle, Alysa E. ; Lasky-Su, Jessica ; Sklar, Pamela B. ; D'Angelo, Eugene ; Gonzalez-Heydrich, Joseph ; Kratochvil, Christopher J ; Mick, Eric ; Klein, Kristy ; Rezac, Amy J. ; Biederman, Joseph. / Linkage analysis of attention deficit hyperactivity disorder. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2008 ; Vol. 147, No. 8. pp. 1387-1391.
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