Linear, redox modified DNA probes as electrochemical DNA sensors

Francesco Ricci, Rebecca Y Lai, Kevin W. Plaxco

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

We show here that hybridization-linked changes in the dynamics of a redox-modified, electrode-bound linear (as opposed to stem-loop) probe DNA produce large changes in Faradaic current, allowing for the ready detection of target oligonucleotides.

Original languageEnglish (US)
Pages (from-to)3768-3770
Number of pages3
JournalChemical Communications
Issue number36
DOIs
StatePublished - Sep 19 2007

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Oligonucleotides
DNA Probes
DNA
Electrodes
Sensors
Oxidation-Reduction

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Linear, redox modified DNA probes as electrochemical DNA sensors. / Ricci, Francesco; Lai, Rebecca Y; Plaxco, Kevin W.

In: Chemical Communications, No. 36, 19.09.2007, p. 3768-3770.

Research output: Contribution to journalArticle

Ricci, Francesco ; Lai, Rebecca Y ; Plaxco, Kevin W. / Linear, redox modified DNA probes as electrochemical DNA sensors. In: Chemical Communications. 2007 ; No. 36. pp. 3768-3770.
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