Light-induced plasticity of synaptic ampa receptor composition in retinal ganglion cells

Rebecca S. Jones, Reed C. Carroll, Scott Nawy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapted mouse retina, we report a retina-specific form of AMPAR plasticity. Both chemical and light activation of NMDARs caused the selective endocytosis of GluA2-containing, Ca2+-impermeable AMPARs on RGCs and replacement with GluA2-lacking, Ca2+-permeable AMPARs. The plasticity was expressed in ON but not OFF RGCs and was restricted solely to the ON responses in ON-OFF RGCs. Finally, the plasticity resulted in a shift in the light responsiveness of ON RGCs. Thus, physiologically relevant light stimuli can induce a change in synaptic receptor composition of ON RGCs, providing a mechanism by which the sensitivity of RGC responses may be modified under scotopic conditions.

Original languageEnglish (US)
Pages (from-to)467-478
Number of pages12
JournalNeuron
Volume75
Issue number3
DOIs
StatePublished - Aug 9 2012

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Neurotransmitter Receptor
Retinal Ganglion Cells
Light
AMPA Receptors
N-Methyl-D-Aspartate Receptors
Retina
Neuronal Plasticity
Endocytosis
Synapses

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Light-induced plasticity of synaptic ampa receptor composition in retinal ganglion cells. / Jones, Rebecca S.; Carroll, Reed C.; Nawy, Scott.

In: Neuron, Vol. 75, No. 3, 09.08.2012, p. 467-478.

Research output: Contribution to journalArticle

Jones, Rebecca S. ; Carroll, Reed C. ; Nawy, Scott. / Light-induced plasticity of synaptic ampa receptor composition in retinal ganglion cells. In: Neuron. 2012 ; Vol. 75, No. 3. pp. 467-478.
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