Lifestyle, occupational, and reproductive factors and risk of colorectal cancer

An Chi Lo, Amr S. Soliman, Hussein M. Khaled, Ahmed Aboelyazid, Joel K. Greenson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

PURPOSE: Lifestyle factors and environmental exposures might help explain the risk of colorectal carcinoma in countries where the incidence is low, but unique patterns of young onset and a high proportion of rectal cancer exist. METHODS: We obtained detailed lifestyle information from 421 patients with colorectal cancer and 439 hospital-controls in Egypt. Logistic regression models were computed to evaluate the risk factors of colorectal carcinoma. RESULTS: A history of pesticide exposure and more frequently eating food directly from farms were significantly associated with a higher risk of colorectal carcinoma (odds ratio = 2.6; 95% CI = 1.1-5.9, and odds ratio = 4.6; 95% CI = 1.5-14.6, respectively). Parous women who reported 7 or more live births or breastfed for 19 months or longer per live birth had a significantly lower risk for colorectal carcinoma (odds ratio = 0.3; 95% CI = 0.2-0.7, and odds ratio = 0.2; 95% CI = 0.1-0.4, respectively). Compared with patients aged 40 years or older, industrial exposures were more common in younger patients (P =.05). CONCLUSIONS: Agricultural and industrial exposures were associated with increased risk of colorectal carcinoma, whereas prolonged lactation and increased parity were inversely associated with colorectal carcinoma in women. Further research to elucidate the biological role of intense environmental and industrial exposures and reproductive factors including lactation may further clarify the etiology of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)830-837
Number of pages8
JournalDiseases of the Colon and Rectum
Volume53
Issue number5
DOIs
StatePublished - May 1 2010

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Life Style
Colorectal Neoplasms
Odds Ratio
Environmental Exposure
Live Birth
Lactation
Logistic Models
Cancer Care Facilities
Egypt
Rectal Neoplasms
Parity
Pesticides
Eating
Food
Incidence
Research

Keywords

  • Colorectal cancer
  • Lifestyle
  • Occupation
  • Reproductive factors
  • Risk factors

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lo, A. C., Soliman, A. S., Khaled, H. M., Aboelyazid, A., & Greenson, J. K. (2010). Lifestyle, occupational, and reproductive factors and risk of colorectal cancer. Diseases of the Colon and Rectum, 53(5), 830-837. https://doi.org/10.1007/DCR.0b013e3181d320b1

Lifestyle, occupational, and reproductive factors and risk of colorectal cancer. / Lo, An Chi; Soliman, Amr S.; Khaled, Hussein M.; Aboelyazid, Ahmed; Greenson, Joel K.

In: Diseases of the Colon and Rectum, Vol. 53, No. 5, 01.05.2010, p. 830-837.

Research output: Contribution to journalArticle

Lo, An Chi ; Soliman, Amr S. ; Khaled, Hussein M. ; Aboelyazid, Ahmed ; Greenson, Joel K. / Lifestyle, occupational, and reproductive factors and risk of colorectal cancer. In: Diseases of the Colon and Rectum. 2010 ; Vol. 53, No. 5. pp. 830-837.
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