Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Dominique S. Michaud, Jacques Izard, Zachary Rubin, Ingegerd Johansson, Elisabete Weiderpass, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus, Rudolf Kaaks, Verena A. Katzke, Heiner Boeing, Jana Foerster, Antonia Trichopoulou, Androniki Naska, Giana Ziara, Paolo Vineis, Sara GrioniDomenico Palli, Rosario Tumino, Amalia Mattiello, Petra H.M. Peeters, Peter D. Siersema, Aurelio Barricarte, José María Huerta, Esther Molina-Montes, Miren Dorronsoro, J. Ramón Quirós, Eric J. Duell, Bodil Ohlsson, Bengt Jeppsson, Anders Johansson, Pernilla Lif, Kay Tee Khaw, Nick Wareham, Ruth C. Travis, Tim J. Key, Heinz Freisling, Talita Duarte-Salles, Magdalena Stepien, Elio Riboli, H. Bas Bueno-De-Mesquita

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Methods: Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. Results: IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Conclusions: Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.

Original languageEnglish (US)
Pages (from-to)1901-1909
Number of pages9
JournalCancer Causes and Control
Volume24
Issue number11
DOIs
StatePublished - Nov 1 2013

Fingerprint

Life Style
Cohort Studies
Bacteria
Antibodies
Periodontal Diseases
Neoplasms
Smoking
Sex Education
Microbiota
Humoral Immunity
Carcinogenesis
Body Mass Index
Chronic Disease
Obesity
Demography
Education

Keywords

  • Antibodies to oral bacteria
  • Lifestyle factors
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Michaud, D. S., Izard, J., Rubin, Z., Johansson, I., Weiderpass, E., Tjønneland, A., ... Bueno-De-Mesquita, H. B. (2013). Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study. Cancer Causes and Control, 24(11), 1901-1909. https://doi.org/10.1007/s10552-013-0265-2

Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study. / Michaud, Dominique S.; Izard, Jacques; Rubin, Zachary; Johansson, Ingegerd; Weiderpass, Elisabete; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Dossus, Laure; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Foerster, Jana; Trichopoulou, Antonia; Naska, Androniki; Ziara, Giana; Vineis, Paolo; Grioni, Sara; Palli, Domenico; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H.M.; Siersema, Peter D.; Barricarte, Aurelio; Huerta, José María; Molina-Montes, Esther; Dorronsoro, Miren; Quirós, J. Ramón; Duell, Eric J.; Ohlsson, Bodil; Jeppsson, Bengt; Johansson, Anders; Lif, Pernilla; Khaw, Kay Tee; Wareham, Nick; Travis, Ruth C.; Key, Tim J.; Freisling, Heinz; Duarte-Salles, Talita; Stepien, Magdalena; Riboli, Elio; Bueno-De-Mesquita, H. Bas.

In: Cancer Causes and Control, Vol. 24, No. 11, 01.11.2013, p. 1901-1909.

Research output: Contribution to journalArticle

Michaud, DS, Izard, J, Rubin, Z, Johansson, I, Weiderpass, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, MC, Clavel-Chapelon, F, Dossus, L, Kaaks, R, Katzke, VA, Boeing, H, Foerster, J, Trichopoulou, A, Naska, A, Ziara, G, Vineis, P, Grioni, S, Palli, D, Tumino, R, Mattiello, A, Peeters, PHM, Siersema, PD, Barricarte, A, Huerta, JM, Molina-Montes, E, Dorronsoro, M, Quirós, JR, Duell, EJ, Ohlsson, B, Jeppsson, B, Johansson, A, Lif, P, Khaw, KT, Wareham, N, Travis, RC, Key, TJ, Freisling, H, Duarte-Salles, T, Stepien, M, Riboli, E & Bueno-De-Mesquita, HB 2013, 'Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study', Cancer Causes and Control, vol. 24, no. 11, pp. 1901-1909. https://doi.org/10.1007/s10552-013-0265-2
Michaud, Dominique S. ; Izard, Jacques ; Rubin, Zachary ; Johansson, Ingegerd ; Weiderpass, Elisabete ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Dossus, Laure ; Kaaks, Rudolf ; Katzke, Verena A. ; Boeing, Heiner ; Foerster, Jana ; Trichopoulou, Antonia ; Naska, Androniki ; Ziara, Giana ; Vineis, Paolo ; Grioni, Sara ; Palli, Domenico ; Tumino, Rosario ; Mattiello, Amalia ; Peeters, Petra H.M. ; Siersema, Peter D. ; Barricarte, Aurelio ; Huerta, José María ; Molina-Montes, Esther ; Dorronsoro, Miren ; Quirós, J. Ramón ; Duell, Eric J. ; Ohlsson, Bodil ; Jeppsson, Bengt ; Johansson, Anders ; Lif, Pernilla ; Khaw, Kay Tee ; Wareham, Nick ; Travis, Ruth C. ; Key, Tim J. ; Freisling, Heinz ; Duarte-Salles, Talita ; Stepien, Magdalena ; Riboli, Elio ; Bueno-De-Mesquita, H. Bas. / Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study. In: Cancer Causes and Control. 2013 ; Vol. 24, No. 11. pp. 1901-1909.
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T1 - Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

AU - Michaud, Dominique S.

AU - Izard, Jacques

AU - Rubin, Zachary

AU - Johansson, Ingegerd

AU - Weiderpass, Elisabete

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Dossus, Laure

AU - Kaaks, Rudolf

AU - Katzke, Verena A.

AU - Boeing, Heiner

AU - Foerster, Jana

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Ziara, Giana

AU - Vineis, Paolo

AU - Grioni, Sara

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Mattiello, Amalia

AU - Peeters, Petra H.M.

AU - Siersema, Peter D.

AU - Barricarte, Aurelio

AU - Huerta, José María

AU - Molina-Montes, Esther

AU - Dorronsoro, Miren

AU - Quirós, J. Ramón

AU - Duell, Eric J.

AU - Ohlsson, Bodil

AU - Jeppsson, Bengt

AU - Johansson, Anders

AU - Lif, Pernilla

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Travis, Ruth C.

AU - Key, Tim J.

AU - Freisling, Heinz

AU - Duarte-Salles, Talita

AU - Stepien, Magdalena

AU - Riboli, Elio

AU - Bueno-De-Mesquita, H. Bas

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Background: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Methods: Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. Results: IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Conclusions: Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.

AB - Background: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Methods: Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. Results: IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Conclusions: Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.

KW - Antibodies to oral bacteria

KW - Lifestyle factors

KW - Smoking

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