Life Ascending: Mechanism and Process in Physiological Adaptation to High-Altitude Hypoxia

Jay F. Storz, Graham R. Scott

Research output: Contribution to journalReview article

Abstract

To cope with the reduced availability of O2 at high altitude, air-breathing vertebrates have evolved myriad adjustments in the cardiorespiratory system to match tissue O2 delivery with metabolic O2 demand. We explain how changes at interacting steps of the O2 transport pathway contribute to plastic and evolved changes in whole-animal aerobic performance under hypoxia. In vertebrates native to high altitude, enhancements of aerobic performance under hypoxia are attributable to a combination of environmentally induced and evolved changes in multiple steps of the pathway. Additionally, evidence suggests that many high-altitude natives have evolved mechanisms for attenuating maladaptive acclimatization responses to hypoxia, resulting in counter-gradient patterns of altitudinal variation for key physiological phenotypes. For traits that exhibit counteracting environmental and genetic effects, evolved changes in phenotype may be cryptic under field conditions and can only be revealed by rearing representatives of high- and low-altitude populations under standardized environmental conditions to control for plasticity.

Original languageEnglish (US)
Pages (from-to)503-526
Number of pages24
JournalAnnual Review of Ecology, Evolution, and Systematics
Volume50
DOIs
StatePublished - Jan 1 2019

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hypoxia
phenotype
vertebrate
vertebrates
environmental effect
acclimation
rearing
breathing
plasticity
plastics
plastic
environmental conditions
air
environmental factors
animal
animals

Keywords

  • adaptation
  • high elevation
  • hypoxia
  • oxygen cascade
  • phenotypic plasticity
  • physiology

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

Life Ascending : Mechanism and Process in Physiological Adaptation to High-Altitude Hypoxia. / Storz, Jay F.; Scott, Graham R.

In: Annual Review of Ecology, Evolution, and Systematics, Vol. 50, 01.01.2019, p. 503-526.

Research output: Contribution to journalReview article

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