Levels of monocyte reactive oxygen species are associated with reduced natural killer cell activity in major depressive disorder

Matthew G. Frank, Shelton E. Hendricks, Diane Bessette, Donald R. Johnson, Julie L. Wieseler Frank, William J. Burke

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Major depressive disorder (MDD) is associated with reductions in natural killer cell activity (NKCA), however the mechanism(s) mediating reduced NKCA in MDD has yet to be determined. In light of evidence that MDD is associated with an inflammatory immune response, we propose that reactive oxygen species (ROS), generated by inflammatory leukocytes (monocytes and/or neutrophils), may mediate the suppression of NKCA in MDD. Intracellular levels of monocyte ROS were significantly associated with reductions in NKCA in outpatients (n = 15) diagnosed with MDD. Sleep disturbance was also significantly correlated with reductions in NKCA. Elevated levels of ROS may be an additional characteristic of a subset of depressed patients in whom an inflammatory response persists and elevations in ROS may, in part, mediate the associations observed between MDD, cardiovascular disease, and cancer.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalNeuropsychobiology
Volume44
Issue number1
DOIs
Publication statusPublished - Jul 20 2001

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Keywords

  • Depression
  • Inflammation
  • Natural killer cells
  • Reactive oxygen species

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Frank, M. G., Hendricks, S. E., Bessette, D., Johnson, D. R., Wieseler Frank, J. L., & Burke, W. J. (2001). Levels of monocyte reactive oxygen species are associated with reduced natural killer cell activity in major depressive disorder. Neuropsychobiology, 44(1), 1-6. https://doi.org/10.1159/000054906