Leukemic transformation in patients with myeloproliferative neoplasms: A population-based retrospective study

Rajesh Shrestha, Smith Giri, James Olen Armitage, Vijaya R Bhatt

Research output: Contribution to journalArticle


Aim: This study determined the epidemiology of developing leukemic transformation in patients with myeloproliferative neoplasms (MPN). Methods: We utilized the Surveillance, Epidemiology and End Results 13 database to identify 83 cases of leukemic transformation in MPN (n = 9335). Results: The 5-year cumulative incidence of leukemic transformation was higher in male versus female (2.17 vs 1.09%; p < 0.001), and in myelofibrosis (2.19%; 95% CI: 1.36-3.34%), compared with essential thrombocythemia (0.37%; 95% CI: 0.19-0.65%) and polycythemia vera (0.72%; 95% CI: 0.46-1.07%; p < 0.001). Patients had a median survival of 2 months after leukemic transformation, worse in older patients and without any impact of prior MPN subtypes. Conclusion: Myelofibrosis has a higher risk of leukemic transformation. Overall survival is dismal regardless of MPN subtypes.

Original languageEnglish (US)
Pages (from-to)1239-1246
Number of pages8
JournalFuture Oncology
Issue number14
Publication statusPublished - Jun 2017



  • acute myeloid leukemia
  • hematologic/leukemia
  • myeloproliferative neoplasm
  • prognosis
  • risk factors
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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