Leptin accelerates autoimmune diabetes in female NOD mice

Giuseppe Matarese, Veronica Sanna, Robert I. Lechler, Nora E Sarvetnick, Silvia Fontana, Seraflno Zappacosta, Antonio La Cava

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

We have recently shown that leptin, the product of the obese gene, can directly influence T-cell function. In the work presented here, we explored the role of leptin in the development of spontaneous autoimmunity in the nonobese diabetic (NOD) mouse, an animal model for the study of human insulin-dependent diabetes mellitus (type 1 diabetes). We found that expression of serum leptin increased soon before the onset of hyperglycemia and diabetes in susceptible females. A pathogenetic role of leptin was assessed by administering recombinant leptin to young female and male NOD mice. Intraperitoneal injections of leptin accelerated autoimmune destruction of insulin-producing β-cells and significantly increased interferon-γ production in peripheral T-cells. These findings indicate that leptin can favor proinflammatory cell responses and directly influence development of autoimmune disease mediated by Th1 responses.

Original languageEnglish (US)
Pages (from-to)1356-1361
Number of pages6
JournalDiabetes
Volume51
Issue number5
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Inbred NOD Mouse
Leptin
Type 1 Diabetes Mellitus
T-Lymphocytes
Intraperitoneal Injections
Autoimmunity
Hyperglycemia
Interferons
Autoimmune Diseases
Animal Models
Insulin
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Matarese, G., Sanna, V., Lechler, R. I., Sarvetnick, N. E., Fontana, S., Zappacosta, S., & La Cava, A. (2002). Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes, 51(5), 1356-1361. https://doi.org/10.2337/diabetes.51.5.1356

Leptin accelerates autoimmune diabetes in female NOD mice. / Matarese, Giuseppe; Sanna, Veronica; Lechler, Robert I.; Sarvetnick, Nora E; Fontana, Silvia; Zappacosta, Seraflno; La Cava, Antonio.

In: Diabetes, Vol. 51, No. 5, 01.01.2002, p. 1356-1361.

Research output: Contribution to journalArticle

Matarese, G, Sanna, V, Lechler, RI, Sarvetnick, NE, Fontana, S, Zappacosta, S & La Cava, A 2002, 'Leptin accelerates autoimmune diabetes in female NOD mice', Diabetes, vol. 51, no. 5, pp. 1356-1361. https://doi.org/10.2337/diabetes.51.5.1356
Matarese G, Sanna V, Lechler RI, Sarvetnick NE, Fontana S, Zappacosta S et al. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes. 2002 Jan 1;51(5):1356-1361. https://doi.org/10.2337/diabetes.51.5.1356
Matarese, Giuseppe ; Sanna, Veronica ; Lechler, Robert I. ; Sarvetnick, Nora E ; Fontana, Silvia ; Zappacosta, Seraflno ; La Cava, Antonio. / Leptin accelerates autoimmune diabetes in female NOD mice. In: Diabetes. 2002 ; Vol. 51, No. 5. pp. 1356-1361.
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