Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart

Lindsay B. Weitzel, Amrut V. Ambardekar, Andreas Brieke, Joseph C. Cleveland, Natalie J. Serkova, Paul E. Wischmeyer, Brian D Lowes

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Heart failure patients have inadequate nutritional intake and alterations in metabolism contributing to an overall energy depleted state. Left ventricular assist device (LVAD) support is a common and successful intervention in patients with end-stage heart failure. LVAD support leads to alterations in cardiac output, functional status, neurohormonal activity and transcriptional profiles but the effects of LVADs on myocardial metabolism are unknown. This study set out to measure cardiac metabolites in non-failing hearts, failing hearts, and hearts post-LVAD support. Methods: The study population consisted of 8 non-ischemic failing (at LVAD implant) and 8 post-LVAD hearts, plus 8 non-failing hearts obtained from the tissue bank at the University of Colorado. NMR spectroscopy was utilized to evaluate differences in myocardial energy substrates. Paired and non-paired t-tests were used to determine differences between the appropriate groups. Results: Glucose and lactate values both decreased from non-failing to failing hearts and increased again significantly in the (paired) post-LVAD hearts. Glutamine, alanine, and aromatic amino acids decreased from non-failing to failing hearts and did not change significantly post-LVAD. Total creatine and succinate decreased from non-failing to failing hearts and did not change significantly post-LVAD. Discussion: Measured metabolites related to glucose metabolism are diminished in failing hearts, but recovered their values post-LVAD. This differed from the amino acid levels, which decreased in heart failure but did not recover following LVAD. Creatine and the citric acid cycle intermediate succinate followed a similar pattern as the amino acid levels.

Original languageEnglish (US)
Article numbere60292
JournalPloS one
Volume8
Issue number4
DOIs
StatePublished - Apr 1 2013

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Left ventricular assist devices
Heart-Assist Devices
heart
Substrates
heart failure
creatine
Heart Failure
Creatine
Metabolism
Succinic Acid
succinic acid
amino acids
metabolism
Metabolites
Tissue Banks
metabolites
functional status
Amino Acids
Glucose
Aromatic Amino Acids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Weitzel, L. B., Ambardekar, A. V., Brieke, A., Cleveland, J. C., Serkova, N. J., Wischmeyer, P. E., & Lowes, B. D. (2013). Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart. PloS one, 8(4), [e60292]. https://doi.org/10.1371/journal.pone.0060292

Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart. / Weitzel, Lindsay B.; Ambardekar, Amrut V.; Brieke, Andreas; Cleveland, Joseph C.; Serkova, Natalie J.; Wischmeyer, Paul E.; Lowes, Brian D.

In: PloS one, Vol. 8, No. 4, e60292, 01.04.2013.

Research output: Contribution to journalArticle

Weitzel, LB, Ambardekar, AV, Brieke, A, Cleveland, JC, Serkova, NJ, Wischmeyer, PE & Lowes, BD 2013, 'Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart', PloS one, vol. 8, no. 4, e60292. https://doi.org/10.1371/journal.pone.0060292
Weitzel LB, Ambardekar AV, Brieke A, Cleveland JC, Serkova NJ, Wischmeyer PE et al. Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart. PloS one. 2013 Apr 1;8(4). e60292. https://doi.org/10.1371/journal.pone.0060292
Weitzel, Lindsay B. ; Ambardekar, Amrut V. ; Brieke, Andreas ; Cleveland, Joseph C. ; Serkova, Natalie J. ; Wischmeyer, Paul E. ; Lowes, Brian D. / Left Ventricular Assist Device Effects on Metabolic Substrates in the Failing Heart. In: PloS one. 2013 ; Vol. 8, No. 4.
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